Kirenol dosage

Kirenol analysis quantifies this bioactive diterpene compound found in several Asian medicinal plants, including Siegesbeckia orientalis , Siegesbeckia pubescens , and Siegesbeckia glabrescens . This secondary metabolite, known for its anti-inflammatory, healing, and antioxidant properties, is used as an analytical marker in the quality control of plant extracts for nutraceutical, pharmaceutical, or cosmetic applications.

The analysis of kirenol is part of a standardization process for plant extracts , guaranteeing their effectiveness, traceability and regulatory compliance.

Kirenol: a bioactive diterpene of therapeutic interest

Kirenol (CAS No. 52659-56-0) is a labdane diterpene isolated primarily from species of the genus Siegesbeckia , known for their traditional use in Asian medicine. These plants are used to treat joint pain, skin inflammation, and various chronic inflammatory conditions.

From a pharmacological perspective, kirenol exhibits several demonstrated biological activities:

• anti-inflammatory action via inhibition of the NF-κB pathway,
• antioxidant and cell-protective properties,
• tissue healing and regenerative effects,
• immunomodulatory and neuroprotective activity.

Because of this wide range of activities, kirenol has become a marker of authenticity and biological potency for extracts of Siegesbeckia and other plants rich in bioactive diterpenes.

Objectives and purpose of kirenol assay

The dosage of kirenol is essential for:

• check the active ingredient content in extracts, powders or supplements,
• standardize plant-based raw materials to ensure batch consistency,
• evaluate the stability of the compound during the transformation processes,
• to control the quality of nutraceutical or cosmetic formulations containing extracts of Siegesbeckia ,
• validate claims related to the anti-inflammatory, healing or antioxidant activity of finished products.

This analysis is a key step in ensuring the reproducibility of the observed physiological effects, as well as compliance with the regulatory requirements of the nutraceutical sector.

Analytical methods used

Kirenol analysis relies on high-precision chromatographic techniques adapted to the quantification of terpene compounds:

• HPLC (high-performance liquid chromatography) : used to separate and quantify kirenol based on its specific UV absorbance profile. This method is recommended for routine controls on standardized extracts.
• LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry) : reference method offering very high sensitivity and selectivity, ideal for complex matrices such as hydroalcoholic extracts or combined formulations.

Depending on the nature of the matrix, a purification step may be applied prior to analysis to eliminate interferences and optimize the detection of the target compound.

For a more complete evaluation of the bioactive profile of the extracts, this analysis can be combined with other services available on the YesWeLab platform, such as the determination of total polyphenols , the determination of flavonoids , or the determination of total diterpenes .

Sectors and applications of kirenol dosage

Kirenol dosage is applicable to several areas:

• Nutraceuticals and phytotherapy : evaluation and standardization of extracts based on Siegesbeckia orientalis used for their anti-inflammatory and joint effects.
• Natural cosmetics : quality control of plant extracts incorporated into soothing, healing and repairing skincare products.
• Animal nutrition : characterization of functional ingredients from medicinal plants for their antioxidant and cell-protective potential.
• Phytochemical research : identification and quantification of kirenol in new plant species or in stability studies of extracts.

This analysis can be complemented by other services from the YesWeLab catalog related to the characterization of bioactive compounds, such as ginsenoside , curcumin , or resveratrol assays . These tests provide a comprehensive view of the phytochemical and functional profile of plant extracts.

Carrying out analyses at YesWeLab

YesWeLab entrusts the kirenol assay to partner laboratories specializing in chromatography and phytochemical analysis. These laboratories are equipped with state-of-the-art HPLC and LC-MS/MS equipment, guaranteeing reliable, reproducible results that comply with international standards.

The majority of our partners are certified or accredited according to the ISO 17025 standard and the COFRAC reference framework, ensuring the quality and traceability of the analyses.

Our scientific team supports manufacturers and formulators at every stage: choosing the analytical method, defining the control plan, interpreting the results, and optimizing extraction processes. Thanks to the YesWeLab digital platform, managing analyses is simplified and secure, from the quote to receiving the reports.

Since 2020, many players in nutraceuticals, natural health and phytochemistry research have trusted YesWeLab for the characterization of plant extracts rich in diterpenes and other active compounds.

Technical data

• CAS No.: 52659-56-0
• Methods: HPLC, LC-MS/MS
• Expertise: Physicochemical
• Business sectors: Nutraceuticals, animal nutrition, plants
• Measured parameters: Kirenol and diterpene derivatives

For any specific request or need for analytical support, contact our team to obtain a personalized quote and recommendations tailored to your plant extracts.