Cinchonine (quinoline alkaloid) dosage

Cinchonine is a natural alkaloid extracted from the bark of the cinchona tree ( Cinchona spp. ), a plant historically used for its febrifuge and antimalarial properties. Structurally related to quinine, cinchonine is less well known, but it plays an important role in the chemical characterization of cinchona-based botanical extracts. It is also being studied for its antioxidant, secondary antimalarial properties, and its potential in nutraceutical formulations.

The dosage of cinchonine is essential in several industrial and scientific contexts:

• Standardization of cinchona extracts or derived products
• Verification of the quality and purity of plant raw materials
• Traceability of food supplements or alkaloid-based products
• Compliance with regulations on alkaloids and bitter substances
• Detection of adulteration or alteration of natural extracts

Proposed analytical methods

Cinchonine analysis is performed by high-performance liquid chromatography (HPLC) or liquid chromatography coupled with mass spectrometry (LC-MS or LC-MS/MS), depending on the matrix to be analyzed and the level of sensitivity required.

• HPLC-DAD : A method commonly used for the separation and quantification of major alkaloids in plant extracts. It allows reliable qualitative monitoring.
• LC-MS/MS : Recommended for complex matrices or multi-component extracts. Offers high specificity and increased sensitivity to detect cinchonine even at low concentrations.

These methods allow precise and reproducible quantification, in accordance with the quality requirements of manufacturers of food supplements, active ingredients or botanical raw materials.

Analyzable matrices

• Dry extracts of cinchona
• Plant raw materials (powders, barks, hydroalcoholic extracts)
• Cinchona-based food supplements
• Standardized products in quinoline alkaloids

Industrial applications

• Formulation of food supplements based on cinchona
• Search for natural antioxidant or bitter active ingredients
• Purity analysis and traceability of plant ingredients
• Assessment of compliance with phytopharmaceutical standards
• Development of new ranges of nutraceutical ingredients from medicinal plants

Why choose YesWeLab?

At YesWeLab, we connect you to a network of accredited laboratories specializing in phytochemical analysis. Our partners are selected based on strict quality criteria (ISO 17025 and COFRAC accreditations) and their analytical expertise in HPLC and LC-MS.

Thanks to our digital platform, you can centralize your analytical needs, manage your samples, and receive your results with ease. Our scientific team will assist you in defining the method best suited to your objectives (R&D, quality control, regulatory compliance).

Recommended internal links

To go further, you can also consult:

• Quinine dosage : parent alkaloid of cinchonine, used in pharmacopoeia and nutraceuticals

Tailor-made support

Since 2020, YesWeLab has been supporting manufacturers, formulators, and distributors in managing their analyses. Whether it's ensuring batch compliance, validating an active ingredient, or developing a new product, our team helps you every step of the way. Contact us for a quote or to discuss your specific needs.