Dosage of secoisolariciresinol DiGlucoside

Secoisolariciresinol diglucoside (SDG) is a plant lignan found primarily in flax seeds ( Linum usitatissimum ), but also in other plants rich in fiber and polyphenols. This compound belongs to the phytoestrogen family, as it is converted in the body into enterolignans (enterodiol and enterolactone), which have biological activities similar to estrogens.

In addition to its phytoestrogenic role, SDG is recognized for its antioxidant properties, contributing to the neutralization of free radicals, and for its potential effects in the prevention of metabolic and cardiovascular diseases.

Importance of SDG measurement

The measurement of secoisolariciresinol diglucoside is an essential tool in several contexts:

• Standardization of flaxseed extracts and other lignan-rich matrices.
• Nutraceutical valorization of functional products claiming antioxidant or hormonal properties.
• Monitoring the stability of formulations over time.
• Regulatory and scientific validation of flax-based food supplements.

This dosage is also useful for laboratories and manufacturers developing health formulations targeting female hormonal well-being, cardiovascular prevention or antioxidant support.

Analytical methods

The analyses are based on high-precision chromatographic techniques:

• HPLC-DAD (high-performance liquid chromatography with UV detection): a method commonly used for the quantification of SDG in standard extracts.
• LC-MS/MS (liquid chromatography coupled with mass spectrometry): reference method for the identification and fine quantification of SDG, even in trace amounts, in complex matrices.

These approaches guarantee reliable and reproducible quantification, in accordance with the quality standards applied to the nutraceutical industry.

Matrices analyzed

The SDG assay is applicable to numerous plant matrices and formulations:

• Whole or processed flax seeds.
• Standardized dry extracts in lignans.
• Dietary supplements in the form of powders, capsules or tablets.
• Food products enriched with functional ingredients based on flax.

Industrial applications

The applications of SDG dosing concern several sectors:

• Nutraceuticals: standardization of flax extracts and validation of health claims.
• Agri-food: development of products enriched with lignans.
• Cosmetics: integration into antioxidant or anti-aging formulations.
• Research and development: clinical and preclinical studies on the phytoestrogenic effects of lignans.

Related analyses in the YesWeLab catalog

For a complete characterization of plant extracts rich in lignans and polyphenols, other assays may be combined:

• Isoflavone assay for the evaluation of phytoestrogens from soybeans.
• Rutin dosage , antioxidant and vasoprotective flavonoid.
• Dosage of salidroside , an adaptogenic phenol derived from Rhodiola.
• Assay of protodioscin , a steroidal saponin used in nutraceuticals.

YesWeLab Expertise

At YesWeLab, we work with a network of partner laboratories selected for their scientific expertise and regulatory compliance (ISO 17025, COFRAC). Our team supports manufacturers in:

• The choice of the analytical method best suited to their matrix.
• Centralized management of analyses via a user-friendly digital platform.
• The guarantee of reliable and reproducible results, in compliance with regulatory and industrial requirements.