Dosage of secoisolariciresinol DiGlucoside

Secoisolariciresinol diglucoside (SDG) is a plant lignan found primarily in flax seeds ( Linum usitatissimum ), but also in other fiber- and polyphenol-rich plants. This compound belongs to the phytoestrogen family, as it is converted in the body into enterolignans (enterodiol and entero-lactone), which have estrogen-like biological activities.

In addition to its phytoestrogenic role, SDG is recognized for its antioxidant properties, contributing to the neutralization of free radicals, and for its potential effects in the prevention of metabolic and cardiovascular diseases.

Interest in SDG dosage

The dosage of secoisolariciresinol diglucoside is an essential tool in several contexts:

• Standardization of flax seed extracts and other lignan-rich matrices.
• Nutraceutical development of functional products claiming antioxidant or hormonal properties.
• Monitoring the stability of formulations over time.
• Regulatory and scientific validation of flax-based food supplements.

This dosage is also useful for laboratories and manufacturers developing health formulations targeting female hormonal well-being, cardiovascular prevention or antioxidant support.

Analytical methods

The analyses are based on high-precision chromatographic techniques:

• HPLC-DAD (high performance liquid chromatography with UV detection): a commonly used method for the quantification of SDG in standard extracts.
• LC-MS/MS (liquid chromatography coupled with mass spectrometry): reference method for the identification and fine quantification of SDG, even in trace amounts, in complex matrices.

These approaches guarantee reliable and reproducible quantification, in accordance with the quality standards applied to the nutraceutical industry.

Analyzed matrices

SDG dosage applies to many plant matrices and formulations:

• Whole or processed flax seeds.
• Dry extracts standardized in lignans.
• Food supplements in the form of powders, capsules or tablets.
• Food products enriched with functional flax-based ingredients.

Industrial applications

Applications of SDG dosage concern several sectors:

• Nutraceuticals: standardization of flax extracts and validation of health claims.
• Food industry: development of products enriched with lignans.
• Cosmetics: integration into antioxidant or anti-aging formulations.
• Research and development: clinical and preclinical studies on the phytoestrogenic effects of lignans.

Related analyses in the YesWeLab catalog

For a complete characterization of plant extracts rich in lignans and polyphenols, other dosages can be associated:

• Isoflavone assay for the evaluation of phytoestrogens from soy.
• Dosage of rutin , an antioxidant and vasoprotective flavonoid.
• Dosage of salidroside , an adaptogenic phenol derived from Rhodiola.
• Dosage of protodioscin , steroidal saponin used in nutraceuticals.

YesWeLab Expertise

At YesWeLab, we work with a network of partner laboratories selected for their scientific expertise and regulatory compliance (ISO 17025, COFRAC). Our team supports manufacturers in:

• The choice of the analytical method adapted to their matrix.
• Centralized management of analyses via an ergonomic digital platform.
• The guarantee of reliable and reproducible results, compliant with regulatory and industrial requirements.