Dosage of ajmalicine (indolic alkaloid)

Ajmalicine , also known as raubasine , is an indole alkaloid naturally present in plants of the genus Rauwolfia , including Rauwolfia serpentina and Rauwolfia vomitoria . This alkaloid is known for its
vasodilatory , neuroprotective and nootropic properties , acting on cerebral microcirculation and blood flow regulation. The dosage of ajmalicine nutraceutical and phytotherapeutic industry to ensure the quality , purity and safety of plant extracts or dietary supplements intended to support cognitive health and circulation.

Analytical methods used

The analysis of ajmalicine is based on high-precision chromatographic techniques allowing the specific detection and quantification of this alkaloid in complex matrices:

• HPLC (High Performance Liquid Chromatography) : A separation technique used with UV detection to measure ajmalicine content in plant extracts and finished formulations.
• LC-MS/MS (Liquid Chromatography coupled with Tandem Mass Spectrometry) : reference method for specific identification and ultra-sensitive quantification, even at trace levels.

reproducible , traceable results that comply with regulatory requirements , whether for quality control, formulation or research.
To learn more about chromatography applied to natural compounds, see the High Performance Liquid Chromatography (HPLC) .

Affected matrices

The dosage of ajmalicine can be carried out on various matrices resulting from plant transformation:

• Dry or hydroalcoholic extracts of Rauwolfia .
• Root or leaf powders.
• Nutraceutical formulations for neuroprotective or vascular .
• Functional ingredients used in natural health products.

These analyses ensure standardization of extracts, guaranteeing the concentration of active ingredients and compliance with batch specifications.

Industrial and scientific applications

Ajmalicine analysis fits into a wide range of applications for the health and nutrition industries:

• Quality control of plant extracts : verification of alkaloid content to ensure consistency between batches.
• Development of nutraceutical products : formulation of supplements intended for cognitive health, memory and cerebral microcirculation.
• Pharmacognostic research : study of the metabolism of indole alkaloids and their biological interactions.
• Regulatory compliance monitoring : compliance with safety thresholds set for active ingredients from Rauwolfia .

The ajmalicine dosage is often associated with other complementary analyses such as the reserpine dosage or the serpentine dosage , also extracted from the same plant, in order to characterize the entire alkaloid profile.

Interest in quality control and research

The quantification of ajmalicine plays a central role in the quality control of botanical extracts and the validation of nutraceutical formulations .
It allows in particular to:

• Check the stability of active ingredients in finished products.
• Evaluate the efficiency of extraction processes.
• Ensure compliance with Good Manufacturing Practices (GMP) .

R&D programs aimed at better understanding the pharmacological effects of indole alkaloids and developing standardized extracts with high added value.

YesWeLab expertise

YesWeLab provides its network of partner laboratories , selected for their expertise in chromatographic and spectrometric analyses, most of which are ISO 17025 and COFRAC accredited . Each analysis is adapted to the client's requirements: matrix, detection threshold, reference method and analytical objective.
Our experts provide personalized support , from the selection of the method to the interpretation of the results, integrating the regulatory constraints specific to the nutraceutical sector.

Since 2020, YesWeLab has been supporting manufacturers, distributors and design offices in their analytical projects thanks to its digital platform : quote requests, sample tracking and access to centralized online results.

For any request for analysis of ajmalicine or other indole alkaloids, contact our scientific team now to obtain a quote or personalized support.