Corynanthine (indole alkaloid) dosage

Corynanthine is an indole alkaloid found primarily in certain Rauwolfia species. This natural compound is known for its adrenolytic activity, i.e., its ability to block certain adrenergic receptors. This property gives it pharmacological and nutraceutical interest, particularly in the context of medicinal plant studies and the search for new biomarkers.

The dosage of corynanthine in the laboratory is essential to standardize plant extracts, identify the presence of specific markers and guarantee the quality of natural formulations.

Importance of dosage

The concentration of indole alkaloids such as corynanthine varies depending on the species, the plant part used, the growing conditions and the extraction process. Accurate dosage is therefore necessary for:

• standardize extracts of Rauwolfia and other associated plants
• ensure the reproducibility of nutraceutical formulations
• research and identify chemical markers of quality
• guarantee regulatory compliance and the safety of finished products
• scientifically support the claims of food supplements and natural products

This analysis is an essential tool for supplement manufacturers, distributors, design offices and researchers working on plant alkaloids.

Available analytical methods

The determination of corynanthine is based on advanced chromatographic techniques, capable of separating and quantifying alkaloids present at low concentrations in complex matrices:

• HPLC (high-performance liquid chromatography): used to reliably and reproducibly separate and quantify indole alkaloids.
• LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry): a reference method for identifying corynanthine and confirming its molecular structure, while allowing extremely sensitive quantification.

These approaches ensure the accuracy needed for research, quality control and regulatory compliance applications.

Affected matrices

Corynanthine dosage can be applied to various plant matrices and formulations:

• crude or standardized extracts of Rauwolfia
• plant powders used in phytotherapy
• nutraceutical formulations and food supplements
• complex preparations containing several bioactive compounds

This analysis is suitable for both raw materials and finished products, allowing complete monitoring of the production chain.

Industrial and scientific applications

Corynanthine analysis is useful in several contexts:

• in nutraceuticals, to ensure the standardization and conformity of plant-based extracts
• in research, to study the biological activity of indole alkaloids and their role as biomarkers
• for distributors and importers, to verify the quality and traceability of batches
• for manufacturers, to guarantee transparency and avoid variations in composition between batches

The dosage of corynanthine is part of a quality control and scientific innovation approach around plant alkaloids.

Additional analyses available

YesWeLab also offers other analyses of indole alkaloids and associated molecules, allowing the analytical profile of plant extracts to be completed:

Reserpine dosage
Yohimbine dosage
Ajmalicine dosage
Quinine dosage
Scopolamine dosage

These services make it possible to characterize plant extracts more completely and to better understand their biological activity.

YesWeLab expertise

YesWeLab works with a network of partner laboratories specialized in physicochemical and plant analyses, rigorously selected and for the most part ISO 17025 certified and COFRAC accredited.

Since 2020, our digital platform has facilitated analysis management for manufacturers, distributors, and design offices. It centralizes requests, enables sample tracking, and ensures the delivery of fast and reliable results.

Our scientific team supports each project with precision and responsiveness, in order to meet specific requirements in terms of quality control and research into bioactive markers.