Corynanthine (indole alkaloid) dosage

Corynanthine is an indole alkaloid found primarily in certain Rauwolfia species. This natural compound is known for its adrenolytic activity, meaning its ability to block certain adrenergic receptors. This property gives it pharmacological and nutraceutical value, particularly in studies on medicinal plants and the search for new biomarkers.

Laboratory corynanthin analysis is essential to standardize plant extracts, identify the presence of specific markers, and guarantee the quality of natural formulations.

Importance of dosage

The concentration of indole alkaloids such as corynanthine varies depending on the species, the plant part used, the growing conditions, and the extraction method. Therefore, precise measurement is necessary to:

• Standardize extracts of Rauwolfia and other related plants
• Ensure the reproducibility of nutraceutical formulations
• Research and identify chemical quality markers
• Guarantee regulatory compliance and the safety of finished products
• Provide scientific support for claims made by food supplements and natural products

This analysis is an essential tool for supplement manufacturers, distributors, research firms and researchers working on plant alkaloids.

Available analytical methods

Corynanthine analysis relies on advanced chromatographic techniques capable of separating and quantifying alkaloids present in low concentrations within complex matrices:

• HPLC (high-performance liquid chromatography): used to reliably and reproducibly separate and quantify indole alkaloids.
• LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry): the reference method for identifying corynanthine and confirming its molecular structure, while also allowing for extremely sensitive quantification.

These approaches ensure the accuracy required for research, quality control, and regulatory compliance applications.

Matrices involved

Corynanthin dosage can be applied to various plant matrices and formulations:

• Crude or standardized extracts of Rauwolfia
• Plant powders used in herbal medicine
• Nutraceutical formulations and food supplements
• Complex preparations containing several bioactive compounds

This analysis is suitable for both raw materials and finished products, allowing for complete monitoring of the production chain.

Industrial and scientific applications

Corynanthin analysis is useful in several contexts:

• In nutraceuticals, to ensure the standardization and conformity of plant-based extracts
• In research, to study the biological activity of indole alkaloids and their role as biomarkers
• For distributors and importers, to verify the quality and traceability of batches
• For manufacturers, to guarantee transparency and avoid variations in composition between batches

The dosage of corynanthine is part of a quality control and scientific innovation approach around plant alkaloids.

Additional analyses available

YesWeLab also offers other analyses of indole alkaloids and associated molecules, allowing for a more complete analytical profile of plant extracts:

Reserpine dosage,
yohimbine dosage,
ajmalicine dosage,
quinine dosage
, scopolamine dosage

These services allow for a more complete characterization of plant extracts and a better understanding of their biological activity.

YesWeLab's expertise

YesWeLab works with a network of partner laboratories specializing in physico-chemical and plant analyses, rigorously selected and mostly ISO 17025 certified and COFRAC accredited.

Since 2020, our digital platform has facilitated the management of analyses for manufacturers, distributors, and engineering firms. It centralizes requests, enables sample tracking, and ensures the delivery of fast and reliable results.

Our scientific team supports each project with precision and responsiveness, in order to meet the specific requirements in terms of quality control and the search for bioactive markers.