Wogonine dosage

Wogonin is a bioactive flavone extracted from the root of Scutellaria baicalensis , an iconic medicinal plant in Asian pharmacopoeia, also known as Baikal skullcap. This molecule is widely studied for its anti-inflammatory, antioxidant, neuroprotective, and anxiolytic effects, making it a preferred ingredient in soothing nutraceutical and cosmetic formulations.

Wogonin is often standardized in extracts to ensure consistent efficacy of skullcap-based products. Its precise dosage is therefore a major concern for manufacturers of supplements, plant extracts, or dermo-cosmetic products with soothing and anti-aging properties.

Analytical methods: HPLC-DAD and LC-MS

Wogonin analysis relies on liquid chromatography methods capable of separating, identifying, and quantifying this flavone in often complex matrices:

• HPLC-DAD (diode array detection): standard method for the determination of wogonin in plant extracts and simple formulations.
• LC-MS (liquid chromatography coupled with mass spectrometry): recommended for samples with low concentration or matrices enriched in similar polyphenolic compounds.

These techniques also allow, on request, to distinguish wogonin from its structural analogues such as baicalein, baicalin or norwogonin, also present in Scutellaria baicalensis .

Why measure wogonine?

Wogonine measurement is a key step in:

• Standardize skullcap extracts used in nutraceutical or cosmetic products.
• To guarantee the effectiveness and consistency of formulations with a soothing or anti-aging effect.
• Promote health and wellness claims, particularly in Asian markets, or supplements targeting stress and the nervous system.
• Meeting the requirements for quality, traceability and regulatory compliance (particularly in the case of export).
• Detect fraud or overdosing, in case of mixing with lower quality standardized extracts.

Matrices involved

Our analytical protocols are suitable for a wide variety of products containing wogonin, including:

• Dry or fluid extracts of Scutellaria baicalensis
• Micronized root powders
• Dietary supplements in the form of capsules, tablets, sticks or sachets
• Soothing infusions and herbal teas
• Cosmetic formulations (serums, creams, lotions with a calming or anti-inflammatory effect)

Each matrix undergoes specific preparation (extraction, purification, filtration) ensuring optimal quantification of the molecule.

Application sectors

The measurement of wogonin is of interest to many industrial players:

• Nutraceuticals: products for stress relief, sleep, chronic inflammation, and cognitive health
• Cosmetics: soothing, anti-redness, and anti-aging skincare products
• Botanical extracts industry: batch quality control, standardization of crude or enriched extracts
• Research and development: pharmacological studies, synergistic effects with other flavonoids

Expert laboratories for your plant extracts

At YesWeLab, we select laboratories specializing in phytochemistry and flavonoid analysis, with recognized expertise in the field of Asian and European plant extracts. Most of our partners are ISO 17025 certified and have the latest chromatography equipment (HPLC-DAD, LC-MS/MS).

Depending on your goals, we help you to:

• Choose the method best suited to your matrix
• Define detection and quantification thresholds that conform to your specifications
• Verify that your products comply with regulatory or marketing requirements

A platform to simplify your analyses

Since 2020, YesWeLab has been supporting manufacturers through a centralized digital platform, enabling them to:

• Easily manage your quote requests
• Track the progress of your analyses
• Access your reports and data online
• Interact with our scientific team for any technical clarification

We provide tailored, fast and rigorous support at every stage of your project.

Further analyses recommended

• Dosage of baicalein (Scutellaria baicalensis)
• Total flavonoid content assay 

Request your personalized quote now

Add this service to your online quote or contact our scientific team for any specific requests. YesWeLab is your trusted partner for the analysis and standardization of your wogonine-based plant extracts.