Synephrine dosage

Synephrine measurement is essential for manufacturers of citrus-based dietary supplements, particularly those containing extracts of Citrus aurantium (bitter orange). This natural amine is often used for its thermogenic, appetite-suppressing, and metabolism-boosting effects. However, its use is heavily regulated in many countries due to its potential cardiovascular effects. Accurate quantification is therefore essential to ensure regulatory compliance and consumer safety.

Analysis by LC-MS/MS or HPLC: reference method for reliable measurement

YesWeLab offers synephrine determination using liquid chromatography-mass spectrometry (LC-MS/MS), a highly sensitive and highly selective analytical method, ideally suited to detecting biogenic amines in complex matrices. The HPLC-DAD method can also be used in certain cases, particularly for internal quality controls or simple matrices.

The analysis is carried out using validated methods, compliant with ISO 17025 standards or the recommendations of European health authorities. Partner laboratories are selected based on their experience with this type of molecule and the technical requirements associated with your request.

Analyzed matrices: from raw to galenic form

There are many matrices accepted for this analysis, including:

• Dry or hydroalcoholic extracts of citrus fruits
• Active ingredients standardized to synephrine
• Plant powders or bulk ingredients
• Finished products in the form of capsules, tablets, powders or liquids
• “Fat-burning” or stimulant food supplements

This analysis makes it possible to determine the actual concentration of synephrine, to identify any excesses and to guarantee compliance with current regulations, particularly in France, Europe and the United States.

Why measure synephrine?

Synephrine dosage has several purposes:

• Regulatory control : The maximum permitted synephrine content is strictly regulated in many countries. In France, ANSES recommends a maximum content of 20 mg/day in food supplements.
• Quality control : verification of the conformity of batches of raw materials and finished products.
• Consumer safety : limiting cardiovascular risks linked to overconsumption.
• Development of active formulas : standardization of the active ingredient to ensure product efficacy and stability.
• Constitution of regulatory files : analytical requirement within the framework of registration or post-marketing control.

Areas covered by this analysis

Synephrine testing is particularly useful in the following areas:

• Dietary supplements for weight loss and metabolism : verification of contents for bitter orange-based formulations.
• Sports nutrition : check for energy or pre-workout products containing citrus extracts.
• Botanical extract industry : standardization of batches of ingredients sold in B2B.
• Importers and distributors : quality control of incoming batches to verify their conformity before marketing.

A network of accredited laboratories to meet your requirements

YesWeLab works with accredited partner laboratories (ISO 17025, COFRAC, etc.) specializing in physical chemistry and natural amine analysis. We adapt our selection based on the nature of your samples, the required sensitivity level, the applicable regulatory context, and your operational constraints (timeframes, budget, results format, etc.).

Simplified management thanks to our digital platform

Our online platform allows you to centralize your analytical needs with ease. Submit your request online, send your samples, track the progress of your analyses, communicate with our scientific team, and retrieve your results in just a few clicks. You gain speed, visibility, and reliability.

Need a specific dosage or regulatory advice?

Our team will assist you in interpreting results and assessing the compliance of your synephrine-containing products. If you have specific constraints (complex formulation, low content, documentary requirements, etc.), please specify them in your request.

Further analyses recommended

• Determination of biogenic amines
• Caffeine Dosage

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