Synephrine dosage

Synephrine dosage is essential for manufacturers of citrus-based dietary supplements, particularly those containing Citrus aurantium (bitter orange) extracts. This natural amine is often used for its thermogenic, appetite-suppressant, and metabolism-boosting effects. However, its use is strictly regulated in many countries due to its potential cardiovascular effects. Accurate quantification is therefore crucial to ensure regulatory compliance and consumer safety.

Analysis by LC-MS/MS or HPLC: the reference method for reliable measurement

YesWeLab offers synephrine quantification by liquid chromatography coupled with mass spectrometry (LC-MS/MS), a highly sensitive and selective analytical method ideally suited for detecting biogenic amines in complex matrices. The HPLC-DAD method can also be used in certain cases, particularly for internal quality control or simple matrices.

The analysis is performed using validated methods, compliant with ISO 17025 standards or the recommendations of European health authorities. Partner laboratories are selected based on their experience with this type of molecule and the technical requirements associated with your request.

Matrices analyzed: from raw material to pharmaceutical form

Numerous matrices are accepted for this analysis, including:

• Dry or hydro-alcoholic extracts of citrus fruits
• Standardized active ingredients in synephrine
• Plant powders or bulk ingredients
• Finished products in the form of capsules, tablets, powders or liquids
• Fat-burning dietary supplements or stimulants

This analysis makes it possible to determine the actual concentration of synephrine, to identify any excesses and to guarantee compliance with the regulations in force, particularly in France, Europe and the United States.

Why measure synephrine levels?

Synephrine measurement serves several purposes:

• Regulatory control : the maximum permitted level of synephrine is strictly regulated in many countries. In France, ANSES recommends a maximum level of 20 mg/day in food supplements.
• Quality control : verification of the conformity of batches of raw materials and finished products.
• Consumer safety : limiting cardiovascular risks linked to overconsumption.
• Development of active formulas : standardization of the active ingredient to guarantee the efficacy and stability of the product.
• Preparation of regulatory files : analytical requirement in the context of registration or post-market control.

Areas covered by this analysis

Synephrine measurement is particularly useful in the following areas:

• Dietary supplements for weight loss and metabolism : checking the content of formulations based on bitter orange.
• Sports nutrition : control of energy or pre-workout products containing citrus extracts.
• Botanical extracts industry : standardization of batches of ingredients sold in B2B.
• Importers and distributors : quality control of incoming batches to verify their conformity before marketing.

A network of accredited laboratories to meet your requirements

YesWeLab works with accredited partner laboratories (ISO 17025, COFRAC, etc.) specializing in physicochemical analysis and natural amine analysis. We tailor our selection based on the nature of your samples, the required sensitivity level, the applicable regulatory context, and your operational constraints (deadlines, budget, results format, etc.).

Simplified management thanks to our digital platform

Our online platform allows you to easily centralize your analytical needs. Submit your request online, send your samples, track the progress of your analyses, communicate with our scientific team, and retrieve your results in just a few clicks. You gain speed, visibility, and reliability.

Do you need a specific dosage or regulatory advice?

Our team will assist you in interpreting the results and assessing the conformity of your synephrine-containing products. If you have specific constraints (complex formulation, low concentration, documentation requirements, etc.), please specify them in your request.

Further analyses recommended

• Assay of biogenic amines
• Caffeine dosage

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