Suramin dosage

Suramin measurement is a sophisticated analysis, primarily performed in applied research or experimental formulation development. A synthetic molecule, suramin is historically known for its antiparasitic properties, but is now primarily used as a pharmacological tool in basic research and some advanced formulation projects. YesWeLab offers its measurement by LC-MS/MS, a highly sensitive and selective method, as well as by HPLC in specific analytical contexts.

What is suramin?

Suramin (CAS: 129-46-4) is a synthetic polysulfone compound, initially developed as a treatment for trypanosomiasis (sleeping sickness) and certain tropical parasitic diseases. Today, its use is focused on applications in pharmacological research, particularly for its action on cellular signaling pathways (purinergic receptors, kinase enzymes, etc.).

In the laboratory, suramin is used to:

• Validate pharmacodynamic effects in experimental formulations,
• Study molecular interactions in model biological systems,
• Evaluate the presence or absence of synthetic residues in complex extracts,
• Test stability or controlled release in targeted solutions.

Why measure suramin?

Suramin dosage is required in several critical situations:

• Verification of the active concentration in test formulations,
• Quality control of experimental solutions or pilot batches,
• Cross-contamination analysis in plant extracts or mixed products,
• Stability studies in complex matrices (solvents, buffer solutions, biochemical mixtures).

It is also used in the preclinical development phase for innovative applications, including tests on biological systems in vitro or ex vivo.

Analytical technique: High sensitivity LC-MS/MS

Given the complex structure of suramin and its physicochemical properties, the dosage is generally carried out by:

• LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry): reference method for achieving high sensitivity and excellent specificity in complex or dilute matrices.
• HPLC-UV: applicable in certain standard cases, when the concentration is high and the matrix is ​​simple.

YesWeLab selects the most suitable method based on the type of sample (aqueous solution, complex extract, formulation under development) and the required detection threshold.

Analyzed matrices

We offer suramin assay on the following matrices:

• Experimental formulations (injectable solutions, products under development),
• Complex extracts in the context of contamination or residue controls,
• Test solutions in the context of biological or chemical tests,
• Samples from academic or industrial R&D projects.

Our partner laboratories are equipped to process these sensitive matrices with validated protocols, in compliance with current quality standards (ISO 17025, GLP depending on the project).

Sectors of application

Suramin dosage mainly concerns the following sectors:

• Biomedical and pharmacological research,
• Development of innovative formulations (biotech, pharma, cosmetics),
• Natural health R&D laboratories wishing to eliminate any risk of cross-contamination,
• Plant extract industry incorporating advanced purity controls.

For broader analyses, it may be useful to combine this assay with other LC-MS/MS tests for active or unwanted substances. For example, see our fact sheet on the assay of yohimbine or piperine for multi-compound analytical profiles.

Why use YesWeLab?

Since 2020, YesWeLab has been facilitating access to complex analytical services for manufacturers, research laboratories, biotech startups, and distributors. Thanks to our network of specialized laboratories, accredited to ISO 17025 or working according to GLP/GLP standards, we select the solution adapted to your needs, your matrix, and your deadline or budget constraints.

Our digital platform allows you to centralize your requests, track your samples, and securely retrieve results. Our scientific team supports you every step of the way, from defining your needs to interpreting your results.

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Do you need suramin testing for a research or quality control project? Entrust your analyses to our expert network.