Stilbestrol Dosage

The stilbestrol (or diethylstilbestrol, DES ) assay aims to detect and quantify this synthetic estrogenic compound banned in human and animal food . Historically used as a growth promoter or hormone treatment, stilbestrol is now strictly banned due to its toxicity, carcinogenic potential and endocrine disrupting effects .

This analysis helps ensure regulatory compliance of agri-food products, nutraceutical supplements and environmental matrices (water, soil, effluents).

Analytical methods

The dosage of stilbestrol is carried out by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) , a reference method for the detection of hormonal compounds at trace levels.

• LC-MS/MS : high sensitivity, molecular specificity, precise quantification down to a few ng/kg.
• Sample preparation: liquid-liquid extraction, solid phase purification (SPE) and validation according to current European standards.

Analyses can follow European guidelines (EC Regulation No. 37/2010) and official ISO and AOAC methods , ensuring full traceability and strict regulatory compliance .

Industrial applications

Stilbestrol analysis applies to many sectors:

• Food industry : detection of synthetic hormone residues in meat, milk, eggs or fish.
• Nutraceuticals and herbal medicine : control of plant raw materials and supplements to exclude any contamination.
• Environment : monitoring of effluents or wastewater to detect the presence of endocrine disruptors.
• Regulatory security : compliance with REACH, EFSA and EC Regulation 1881/2006 requirements.

Analyzed matrices

• Animal products (meat, milk, eggs)
• Surface water, groundwater, wastewater
• Food supplements and plant extracts
• Environmental and biotechnological matrices

Further analyses recommended

For a complete control of hormonal and endocrine disrupting compounds, YesWeLab recommends:

• Bisphenol A assay : detection of a common endocrine disruptor in packaging,
• Phthalate determination : analysis of plasticizers with hormonal activity,
• SVHC test – Substances of very high concern : global screening according to the REACH regulation,
• Nonylphenol dosage : monitoring of surfactants with estrogenic potential.

YesWeLab expertise

Thanks to its network of ISO 17025 certified and COFRAC accredited partner laboratories , YesWeLab guarantees reliable, traceable analyses that comply with European standards .
Our digital platform centralizes your analytical needs: quote requests, sample tracking and online results receipt.

Need regulatory-compliant stilbestrol testing?
Contact our scientific team now for personalized support and high-precision analysis.