Stachyrin assay

Stachydrine analysis is a key step in quality control of medicinal plant extracts, particularly those derived from motherwort ( Leonurus japonicus ) or other plants rich in natural alkaloids. Used as a standardization marker, stachydrine is recognized for its cardiovascular, sedative, and tonic properties. At YesWeLab, we primarily offer stachydrine analysis using LC-MS (liquid chromatography coupled with mass spectrometry), or HPLC as needed, to ensure reliable quantification even at very low concentrations.

What is stachhydrin?

Stachydrine (CAS: 471-87-4) is a naturally occurring proline betaine alkaloid found in several plant species, including Leonurus japonicus (motherwort), Citrus spp., and Stachys spp. It is widely studied for its hypotensive, cardioprotective, antioxidant, and neuroactive effects. In traditional Asian medicine, stachydrine is used as an active ingredient in preparations for female reproductive health and cardiovascular regulation.

In modern formulations, its presence is exploited in:

• dietary supplements with circulatory or soothing properties,
• phytotherapeutic formulations incorporating standardized extracts of medicinal plants,
• Natural functional products that enhance their content of active plant ingredients.

Importance of stachydrine measurement

Stachyhydrin levels can be measured to:

• Standardize plant extracts to guarantee a consistent concentration of active ingredient,
• To authenticate the botanical origin of a plant extract or powder,
• Verify the conformity of raw materials intended for gentle therapeutic use
• Monitor the stability of formulations over time,
• To meet regulatory requirements for quality control.

This dosage is therefore essential for manufacturers and formulators wishing to secure and enhance the value of their natural products.

Available analytical methods

YesWeLab offers stachydrine assay using the following techniques:

• LC-MS: preferred method for its high sensitivity and specificity, ideal for detecting stachydrin in complex matrices or at very low concentrations.
• HPLC-DAD: a possible alternative in simple matrices, when the concentrations are sufficient for reliable UV detection.

The selection of the method will depend on the matrix to be analyzed, the desired detection thresholds, and the regulatory or normative context of your product.

Commonly analyzed matrices

Our partner laboratories can measure stachydrine in a wide range of matrices:

• Dry or hydroalcoholic extracts of Leonurus japonicus or other plants,
• Raw or standardized vegetable powders,
• Dietary supplements in the form of capsules, tablets or liquid solutions,
• Herbal blends for cardiovascular or relaxation purposes.

Each method is validated according to rigorous protocols, in compliance with the requirements of the ISO 17025 standard.

Sectors of application

The stachydrine assay is intended for industry professionals:

• Nutraceuticals: manufacturers of plant-based supplements,
• Phytotherapy: natural formulation laboratories,
• Quality control: validation of raw materials or finished products,
• R&D: characterization of active ingredients in the context of the development of new health products.

It is also recommended to combine this dosage with other phytochemical markers for a complete profile. For example, explore our analyses of rhoeadine for calming extracts, or rosmarinic acid for plants with antioxidant activity.

Why choose YesWeLab?

Since 2020, YesWeLab has been supporting professionals in the plant and nutraceutical industries with their analytical projects. We rely on a network of accredited laboratories (ISO 17025, COFRAC, etc.), selected based on the matrix, the required analytical technique, and your regulatory needs.

Our digital platform allows you to easily manage your analysis requests, track your samples, and receive results. Our scientific team provides guidance throughout the entire process to ensure reliable and actionable results.

Get your personalized quote

Do you want to measure stachydrine in a plant extract or a natural formulation? Our team will help you define the best method and offer you a laboratory suited to your specific needs.