Sennosides dosage

Sennosides are anthracene glycosides naturally present in the leaves and pods of senna ( Senna alexandrina Sennosides A and B represent the most studied and standardized forms in plant preparations.

Interest in sennoside dosage

The dosage of these compounds is essential for several reasons:

• Guarantee the effectiveness of food supplements or senna-based products.
• Respect the safety limits set by health authorities to avoid adverse effects linked to excessive consumption.
• Standardize plant extracts to ensure a constant and reproducible concentration of sennosides.
• Control the quality of raw materials and verify the conformity of production batches.

Analytical methods

The analysis of sennosides is mainly based on chromatographic techniques adapted to the complexity of plant extracts:

• HPLC-DAD (liquid chromatography with UV-DAD detection), reference method for the quantification of sennosides A and B.
• HPTLC (high performance thin layer chromatography), used for rapid batch checks.
• LC-MS/MS, offering high sensitivity and the ability to detect and quantify sennosides in complex or low concentration matrices.

Analyzed matrices

The dosage of sennosides applies to various plant matrices and formulations:

• Senna extracts in powder or liquid form.
• Herbal teas and infusions made from senna leaves or fruits.
• Capsules and tablets formulated for their natural laxative effects.
• Multi-ingredient food supplements incorporating senna as the main active ingredient.

Industrial applications

This analysis is particularly relevant in the following sectors:

• Nutraceuticals: validation of the active concentration in food supplements for digestive purposes.
• Medicinal plants: quality control and certification of raw materials.
• Food industry: monitoring of formulations enriched with plant extracts.
• Scientific and clinical research: pharmacological studies on the efficacy and safety of anthracenosides.

Related analyses in the YesWeLab catalog

For a complete characterization of anthraquinones and other plant active ingredients, it is possible to combine:

• Dosage of aloin, another anthraquinone used as a natural laxative.
• Dosage of chrysophanol , anthraquinone with laxative and anti-inflammatory properties.
• Dosage of emodin , a bioactive anthraquinone often associated with senna.

YesWeLab Expertise

At YesWeLab, we collaborate with a network of carefully selected laboratories, most of which are ISO 17025 certified and COFRAC accredited. Our team supports manufacturers and formulators in:

• The choice of the appropriate analysis method according to the matrix.
• Centralization of analyses via an intuitive digital platform.
• The delivery of reliable results that comply with regulatory and quality requirements.