Scopolamine dosage

Scopolamine analysis quantifies this tropane alkaloid, which is naturally present in certain plants of the Solanaceae (notably Datura stramonium , Atropa belladonna , and Hyoscyamus niger ).
Due to its potent neuroactive (anticholinergic, sedative, and hallucinogenic), scopolamine is strictly regulated . Its measurement is essential to ensure the safety, compliance, and traceability of plant-based products.

Analytical methods

The analysis is carried out by liquid chromatography coupled with mass spectrometry (LC-MS/MS) , a reference method for the detection and quantification of tropane alkaloids at very low concentrations.

• LC-MS/MS : high sensitivity, selectivity and reproducibility.
• Possibility of simultaneous dosing with other alkaloids such as atropine and hyoscyamine .
• Compliance with European guidelines (EU Regulation No. 2021/1408) relating to natural contaminants in food and supplements .

Industrial applications

Scopolamine testing is applicable in various contexts:

• Control of plant extracts used in food supplements or plant protection products.
• Monitoring of plant raw materials potentially contaminated by toxic plants (e.g., cross-contamination in batches of tea or dried herbs).
• Regulatory control for placing plant-based products on the market.
• Toxicological and pharmacognosic analysis for research and development.

Matrices analyzed

• Plant extracts (leaves, stems, seeds)
• Dietary supplements
• Infusions, herbal teas, plant powders
• Plant protection products and botanical formulations

Further analyses recommended

For complete control of plant alkaloids and contaminants, YesWeLab recommends:

• Atropine dosage : tropane alkaloid associated with scopolamine,
• Hyoscyamine assay : active isomer of atropine,
• Nicotine assay : detection of natural alkaloids in plants or extracts,
• Pyrrolizidine assay : search for other toxic plant alkaloids.

YesWeLab's expertise

YesWeLab relies on a network of partner laboratories accredited to ISO 17025 and COFRAC standards , specializing in the analysis of plant alkaloids and natural contaminants .
Thanks to our intuitive digital platform , you can centralize your analytical requests , track your samples , and access your results online with ease.

Need to control the scopolamine content in your plant extracts?
Contact our scientific team now for a precise analysis that complies with regulatory requirements.