Sanguinarine dosage

Sanguinarine is an alkaloid belonging to the benzophenanthridine family, primarily extracted from plants such as Sanguinaria canadensis (bloodroot) and Chelidonium majus antimicrobial , anti-inflammatory , and antioxidant effects .

In herbal medicine, it is sometimes used in formulations intended for oral hygiene (gels, mouthwashes) or in topical products for soothing purposes. However, due to its potential toxicity at high doses , controlling its concentration in extracts and finished products is essential.

Interest in the dosage of sanguinarine

Sanguinarine dosage plays a key role for nutraceutical, natural health product and functional cosmetic manufacturers. It allows:

• Ensure safety of use in formulations by controlling the maximum permitted contents.
• Standardize plant extracts to ensure a homogeneous and reproducible composition.
• Support functional claims (antimicrobial, soothing, antioxidant activity).
• Comply with regulatory requirements governing the use of plant alkaloids in foodstuffs and cosmetic products.

Analytical methods used

The dosage of sanguinarine is based on precise and reliable chromatographic techniques:

• HPLC-DAD/UV : reference method for robust quantification in crude extracts.
• LC-MS/MS : more specific and sensitive method, capable of detecting and quantifying the molecule even in trace amounts in complex matrices.

These approaches also allow the differentiation of sanguinarine from other alkaloids present in the same plants, thus ensuring a selective and reliable analysis.

Affected matrices

Sanguinarine analyses can be applied to various plant matrices or finished products:

• Extracts of medicinal plants (Sanguinaria canadensis, Chelidonium majus).
• Cosmetic formulations : oral gels, lotions, skin creams.
• Food supplements based on adaptogenic or purifying plants.
• Technical products incorporating natural extracts with antimicrobial properties.

Industrial applications

Controlling sanguinarine levels is particularly important for:

• Manufacturers of natural health products to ensure safety of use and avoid toxic concentrations.
• Cosmetic manufacturers who use plant extracts rich in alkaloids.
• Phytotherapy stakeholders , to standardize botanical extracts and strengthen their scientific credibility.

Related analyses in the YesWeLab catalog

The dosage of sanguinarine can be supplemented by other analyses of alkaloids and bioactive compounds:

• Dosage of corynanthine , a plant alkaloid with adrenolytic activity.
• Dosage of convallatoxin , a cardiotonic glycoside extracted from lily of the valley.
• Dosage of emetine, an isoquinoline alkaloid with antiparasitic properties.
• Dosage of berberine , another major plant alkaloid with antimicrobial properties.

These associated analyses make it possible to obtain a complete profile of the active plant ingredients present in a raw material or a finished product.

YesWeLab Expertise

At YesWeLab, we work with a network of carefully selected laboratories, accredited or certified according to international standards (ISO 17025, COFRAC). Our scientific team advises you on the method best suited to your needs, taking into account the matrices to be analyzed and specific regulatory requirements.

Since 2020, YesWeLab has been supporting nutraceutical, cosmetic and plant extract manufacturers in their analytical processes, thanks to a centralized digital platform allowing you to easily manage your analyses, from ordering to monitoring results.