OECD dosage

The OECD assay covers all the standardized tests developed by the Organisation for Economic Co-operation and Development (OECD) for the scientific evaluation of chemical substances. These methods, codified in the form of OECD Guidelines for the Testing of Chemicals , cover a wide spectrum of analyses: physicochemical properties, toxicology, ecotoxicology, biodegradability, bioaccumulation, and effects on health or the environment.

These tests are an international benchmark for demonstrating the safety, stability and regulatory compliance of active substances, ingredients, formulations or finished products.
They are essential in the context of regulations such as:

• The REACH Regulation (EC No. 1907/2006) on the Registration, Evaluation, and Authorisation of Chemicals.
• The CLP (Classification, Labelling, Packaging) regulation .
• Biocide, phytosanitary, cosmetic and food regulations .

OECD methods guarantee reproducible, comparable and internationally recognised results , thus facilitating the marketing and regulatory recognition of products in several member countries.

Associated analytical methods and techniques

The term “OECD assay” does not refer to a single method, but to a family of standardized protocols covering various analytical fields. Depending on the nature of the substance and the regulatory objective, the techniques used may include:

• Physicochemical analyses : measurement of flash point, solubility, vapor pressure, partition coefficient (OECD 105, 107, 112, 114, etc.).
• Toxicological analyses : skin irritation tests (OECD 439), sensitization (OECD 406), or skin absorption (OECD 428).
• Ecotoxicological analyses : toxicity on algae (OECD 201), daphnia (OECD 202) or fish (OECD 203).
• Environmental analyses : biodegradability (OECD 301, 302), bioaccumulation (OECD 305).
• Instrumental analytical methods : HPLC , GC-MS , UV-Vis spectrophotometry , ICP-MS , or even in vitro biological tests .

These strictly regulated protocols make it possible to obtain reliable quantitative data on the chemical, toxicological and environmental properties of a substance.

To learn more about some of these techniques, check out:

• chromatography (HPLC) for the quantification of organic compounds.
• Spectrophotometric analysis for the measurement of optical and colorimetric parameters.
• The OECD 101 (UV-VIS Absorption Spectra) test dedicated to the study of optical properties and molecular interactions.

Affected matrices and areas of application

OECD tests can be carried out on a wide range of matrices depending on the nature of the product:

• Raw chemicals or complex mixtures.
• Cosmetic products or active ingredients.
• Feed and additives for animal nutrition.
• Materials and polymers subject to specific environmental conditions.
• Biocidal or phytosanitary preparations.
• Environmental samples : soils, sediments, water, sludge, effluents, etc.

These analyses are particularly important for players in animal nutrition , cosmetics , the chemical industry , and environmental biotechnologies , who must justify the safety and regulatory compliance of their products.

Industrial and regulatory applications

The use of OECD tests is essential for:

• Demonstrate the safety of an ingredient or formulation before marketing.
• Obtain or renew a marketing authorization (MA).
• Support REACH, CLP or biocides files.
• Assess the environmental impact of substances released into natural environments.
• Optimize product formulation to reduce their toxicity and improve their biodegradability.

These analyses form the basis of chemical risk studies and guarantee the transparency and compliance of products with international standards.

YesWeLab expertise

YesWeLab provides a network of ISO 17025 and COFRAC accredited partner laboratories , several of which have the GLP (Good Laboratory Practice) certification required for OECD testing.
Our experts support manufacturers and design offices in:

• Choosing the appropriate OECD test depending on the product and the regulatory framework.
• Analytical compliance and preparation of regulatory files .
• Interpretation of results and their integration into safety or environmental impact studies.

Thanks to the YesWeLab digital platform , the management of regulatory analyses is simplified: submission of requests, sample tracking, receipt of reports and secure archiving.

To complete your regulatory process, also discover:

• test – Skin absorption for biocidal or cosmetic substances.
• OECD 301 Biodegradability Analysis for Environmental Impact Assessment.

For any regulatory testing request, contact our scientific team now to benefit from comprehensive support.