OECD Dosage

OECD testing encompasses all the standardized tests developed by the Organisation for Economic Co-operation and Development (OECD) for the scientific evaluation of chemical substances. These methods, codified as OECD Guidelines for the Testing of Chemicals , cover a wide range of analyses: physicochemical properties, toxicology, ecotoxicology, biodegradability, bioaccumulation, and effects on health or the environment.

These tests constitute an international benchmark for demonstrating the safety, stability, and regulatory compliance of active substances, ingredients, formulations, or finished products.
They are essential within the framework of regulations such as:

• The REACH regulation (EC No. 1907/2006) concerning the registration, evaluation and authorization of chemical substances.
• The CLP (Classification, Labelling, Packaging) regulation .
• Biocidal, phytosanitary, cosmetic and food regulations .

OECD methods guarantee reproducible, comparable and internationally recognized results , thus facilitating the marketing and regulatory recognition of products in several member countries.

Associated analytical methods and techniques

The term “OECD assay” does not refer to a single method, but to a family of standardized protocols covering a variety of analytical fields. Depending on the nature of the substance and the regulatory objective, the techniques used may include:

• Physico-chemical analyses : measurement of flash point, solubility, vapor pressure, partition coefficient (OECD 105, 107, 112, 114, etc.).
• Toxicological analyses : skin irritation tests (OECD 439), sensitization tests (OECD 406), or skin absorption tests (OECD 428).
• Ecotoxicological analyses : toxicity on algae (OECD 201), daphnia (OECD 202) or fish (OECD 203).
• Environmental analyses : biodegradability (OECD 301, 302), bioaccumulation (OECD 305).
• Instrumental analytical methods : HPLC , GC-MS , UV-Vis spectrophotometry , ICP-MS , or in vitro biological assays .

These strictly controlled protocols make it possible to obtain reliable quantitative data on the chemical, toxicological and environmental properties of a substance.

To learn more about some of these techniques, see:

• chromatography (HPLC) for the quantification of organic compounds.
• Spectrophotometric analysis for the measurement of optical and colorimetric parameters.
• The OECD 101 (UV-VIS Absorption Spectra) test is dedicated to the study of optical properties and molecular interactions.

Affected matrices and areas of application

OECD tests can be performed on a wide range of matrices depending on the nature of the product:

• Raw chemical substances or complex mixtures.
• Cosmetic products or active ingredients.
• Animal feed and additives.
• Materials and polymers subjected to specific environmental conditions.
• Biocidal or phytosanitary preparations.
• Environmental samples : soils, sediments, water, sludge, effluents, etc.

These analyses are particularly important for players in animal nutrition , cosmetics , the chemical industry , and environmental biotechnology , who need to justify the safety and regulatory compliance of their products.

Industrial and regulatory applications

The use of OECD tests is essential for:

• Demonstrate the safety of an ingredient or formulation before marketing.
• Obtaining or renewing a marketing authorization (MA).
• Supporting REACH, CLP or biocides dossiers.
• Assess the environmental impact of substances released into natural environments.
• Optimize product formulation to reduce toxicity and improve biodegradability.

These analyses form the basis of chemical risk studies and guarantee the transparency and conformity of products to international standards.

YesWeLab expertise

YesWeLab provides access to a network of partner laboratories accredited to ISO 17025 and COFRAC standards , several of which hold the GLP (Good Laboratory Practices) certification required for OECD testing.
Our experts support manufacturers and engineering firms in:

• The choice of the appropriate OECD test based on the product and the regulatory framework.
• Analytical compliance and preparation of regulatory files .
• The interpretation of the results and their integration into safety or environmental impact studies.

Thanks to the YesWeLab digital platform , the management of regulatory analyses is simplified: application submission, sample tracking, report receipt and secure archiving.

To complete your regulatory process, also check out:

• test 428 – Skin absorption for biocidal or cosmetic substances.
• OECD 301 biodegradability analysis for environmental impact assessment.

For any regulatory testing request, contact our scientific team now to benefit from comprehensive support.