Nobiletin (flavone) dosage

Nobiletin flavone naturally present in citrus peels, particularly mandarin (Citrus reticulata). It is known for its anti-inflammatory, lipid-lowering, neuroprotective, and anticancer effects.

The dosage of nobiletin is essential for:

• Standardize plant extracts used in nutraceuticals or food supplements
• Control the content of active ingredients in enriched formulations
• Valorizing citrus by-products in a circular economy approach
• Meet regulatory or labeling file requirements
• Check the conformity of extracts for therapeutic or functional use

Methodology

The analysis is performed by HPLC-DAD (UV detection around 330 nm) or LC-MS/MS for better sensitivity and specificity. The protocol includes:

• Hydroalcoholic or methanolic extraction from solid or liquid matrices
• Filtration and possible purification (SPE or centrifugation)
• Chromatographic analysis with calibration curve on nobiletin standard

The choice of method depends on the complexity of the matrix and the desired level of precision (quantification or simple detection).

Affected matrices

• Citrus peels (mandarin, sweet orange, kumquat)
• Titrated or untitrated plant extracts
• Dried or freeze-dried vegetable powders
• Nutraceutical capsules, tablets or liquids
• Flavonoid-enriched functional drinks
• Natural cosmetic formulations containing citrus extracts

Industrial applications

• Food supplements and antioxidant extracts
• Functional food (drinks, fortified powders)
• Natural cosmetics (anti-aging care, radiance, antioxidants)
• Research in health nutrition and plant pharmacology
• Valorization of co-products from the juice and essential oil industry

Why choose YesWeLab?

YesWeLab connects you with laboratories specialized in the analysis of citrus flavonoids , accredited ISO 17025. Our partners have the necessary equipment (HPLC, LC-MS/MS) and extensive expertise in developing analytical methods for complex extracts.

See also:

• Hesperidin Dosage
• Narirutin Dosage
• Diosmin dosage