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MDI (diphenylmethane diisocyanate) assay

MDI (diphenylmethane diisocyanate) assay

Technique(s)
Categories: ,
Sector of activity
Expertise

Physicochemical, Nutritional

CAS No.

9016-87-9

Method

Description

Diphenylmethane diisocyanate (MDI) is a chemical compound widely used in the manufacture of polyurethane foams, adhesives, coatings, and composite materials. Classified as a sensitizing and potentially toxic substance, its measurement is crucial for assessing exposures, verifying regulatory compliance (REACH, occupational safety), or monitoring residues in finished materials. Analysis is typically performed by high-performance liquid chromatography (HPLC) after derivatization of the isocyanate groups, often coupled with UV detection or chromatography-mass spectrometry (LC-MS). This measurement is applicable to polymers, paints, adhesives, technical textiles, or air samples collected in the workplace.

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