Madecassic acid dosage

Madecassic acid (CAS 18449-41-7) is a pentacyclic triterpene derived from the plant Centella asiatica , also known as Gotu Kola. This natural compound, with recognized pharmacological properties, is particularly prized in the cosmetic, nutraceutical and dermatological fields for its healing, anti-inflammatory and skin repairing effects. It is often found alongside other active compounds such as asiaticoside or asiatic acid in standardized extracts of Centella.

Why measure madecassic acid?

The dosage of madecassic acid is essential in several industrial contexts:

• Quality control of plant extracts based on Centella asiatica
• Verification of the active concentration in dermocosmetic formulations (creams, gels, repair serums)
• Standardization of food supplements to ensure a minimum content of active triterpenes
• Regulatory or marketing control in the context of health or skin claims

Madecassic acid content is often considered an indicator of therapeutic performance in healing, soothing or anti-aging products.

Analysis methods used

YesWeLab offers the analysis of madecassic acid using high-precision techniques, adapted to complex matrices:

• HPLC-DAD: high-performance liquid chromatography with diode-array detection, for reliable quantification of triterpenes.
• LC-MS/MS: liquid chromatography coupled with tandem mass spectrometry, recommended for low-content or highly interfered matrices (cosmetics, oily complexes, etc.).

The methods applied are validated and comply with good analytical practices (GLP).

Affected matrices

Analyses can be carried out on a wide variety of media:

• Standardized extracts of Centella asiatica
• Dry or powdered plant raw materials
• Formulated cosmetic products (creams, balms, serums)
• Food supplements (powders, capsules, tablets, oral solutions)
• Complex galenic preparations based on phytocomplexes or associated active ingredients

Related analyses in the YesWeLab catalog

Madecassic acid testing is often part of a broader analysis strategy for Centella extracts or restorative products. YesWeLab offers several additional services, including the most commonly requested:

• Assay of asiaticoside
  → Bioactive triterpenic saponin, used as a quality marker in hydrophilic extracts of Centella.
• HPLC profile of total triterpenes
  → Allows a complete mapping of the triterpene compounds present in the extract, useful for formulation or research laboratories.
• Total polyphenols assay
  → Useful for characterizing complementary antioxidant activity in plant extracts used for skin or anti-aging purposes.

These analyses can be integrated into complete quality control plans, according to your regulatory requirements (ISO, EFSA, COSMOS) or your marketing objectives (active claims, clean beauty claims, etc.).

YesWeLab, your partner in phytochemical analyses

As an expert laboratory analysis platform, YesWeLab centralizes a network of partner laboratories highly specialized in phytoconstituents for you. Our laboratories are selected for their technical rigor, responsiveness, and accreditations (ISO 17025, COFRAC, etc.).

Thanks to our digital platform, you benefit from tailored support, simplified sample tracking, and complete traceability of your analyses. Since 2020, numerous manufacturers, cosmetic formulators, and nutraceutical players have trusted us to guarantee the quality, compliance, and efficacy of their plant extracts.

Contact us for your analysis project

Are you developing a Centella asiatica extract? Do you want to validate the madecassic acid concentration in a finished product or raw material? Describe your needs to us – our scientific team will offer you a reliable, fast analytical solution tailored to your specifications.