Lucidin dosage
| Expertise | Physicochemical, Nutritional |
|---|---|
| CAS No. | 478-08-0 |
Description
Lucidin is a natural anthraquinone primarily extracted from Rubia tinctorum a red vegetable dye, it is also known for its biological activities (antioxidant, antimicrobial). However, its genotoxic potential makes it a molecule that requires close monitoring, particularly in extracts intended for food or nutraceutical use.
Therefore, measuring lucidin levels is crucial in the context of:
- quality control of plant extracts
- safety of finished products containing anthraquinone-bearing plants
- regulatory compliance, particularly with regard to European regulations on food supplements and high-risk ingredients
Analysis Methodology
The analysis of lucidin relies on high-precision chromatographic techniques:
- HPLC-DAD (UV detection between 254 and 430 nm depending on the matrix)
- LC-MS or LC-MS/MS for complex or low-concentration extracts
- Extraction adapted according to the matrix (hydroalcoholic solvent or mild acid for dry plants)
The methods are generally developed on C18 columns, in reversed phase, with elution in acetonitrile or methanol gradient.
Affected matrices
- Dry extracts of Rubia tinctorum , Morinda , etc.
- Plant powders for nutraceutical use
- Capsules and formulations based on medicinal plants
- Natural cosmetic products or plant-based colorants
Industrial applications
- Standardization of madder extracts and control of the anthraquinone profile
- Verification of the absence or compliance with regulatory thresholds for high-risk ingredients
- Development of natural formulations incorporating bioactive or coloring molecules
- Meeting the requirements of regulatory agencies regarding the safety of food supplements and cosmetics
And also:
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