Isogentisin dosage

Isogentisin is a xanthone characteristic of gentian roots (Gentiana spp.), a plant known for its bitter properties and long used in herbal medicine and the food industry. This compound is particularly studied as a marker molecule in the standardization of extracts of gentian and other bitter plants. Its dosage helps to guarantee the quality of plant raw materials, but also to ensure consistency in the formulation of food supplements, bitter drinks, pharmaceutical preparations and tinctures.

Importance of Isogentisine Dosage
Isogentisine analysis is of particular importance in several areas:
The nutraceutical and dietary supplement sector, where it is used to standardize gentian extracts used for their digestive and stimulant effects.
The beverage industry, with the quality control of herbal bitter liqueurs, aperitifs, and tonics.
Phytotherapy and herbalism, for the identification and quantification of the compound in therapeutic preparations.
Conformity control, with the verification of the stability of finished products and the monitoring of manufacturing processes.

Analytical Methods
Isogentisin is measured using high-performance liquid chromatography (HPLC-DAD) or LC-MS, two benchmark techniques for analyzing polyphenolic and xanthone compounds. The HPLC-DAD method separates and quantifies isogentisin by detecting its characteristic UV spectrum. The LC-MS approach offers increased sensitivity and allows for reliable quantification, even in complex matrices such as hydroalcoholic extracts, tinctures, or concentrated formulations. These methods guarantee high precision and reproducibility, essential for quality control and research.

Matrices concerned
The dosage of isogentisin is particularly suitable for extracts of gentian and other bitter plants, liquid preparations such as tinctures or hydroalcoholic extracts, finished products such as bitter drinks, liqueurs and food supplements, as well as root powders and dry formulations.

Associated analyses in our catalog
The dosage of isogentisin can be supplemented by other relevant analyses such as the dosage of gentiopicroside , another major marker of gentian, the dosage of swertiamarin , a bitter iridoid also used as a quality indicator, the dosage of luteolin , a flavonoid present in many medicinal plants, or the analysis of total flavonoids for a global characterization of the extracts. This combined approach allows a complete standardization of plant extracts and a better control of the quality of raw materials.

YesWeLab Support
At YesWeLab, we work with a network of specialized, certified, and/or accredited (ISO 17025, COFRAC, etc.) partner laboratories. We select the most suitable laboratory based on your analytical needs, the type of matrix, and the required methods. Our scientific team supports you every step of the way, from defining your analytical needs to interpreting your results. Since 2020, we have earned the trust of numerous manufacturers, distributors, and design offices thanks to our digital platform, which centralizes the management of your analyses and simplifies the tracking of your samples.

Isogentisine testing is an essential tool for nutraceutical, herbal medicine, and food manufacturers. It not only ensures product compliance with quality standards, but also ensures consistency and traceability, essential in a market where transparency and reliability are paramount. Contact our team today to organize your analyses and ensure the quality of your plant extracts and formulations.