Dosage of kavain (kavalactone)

Kavain is a molecule belonging to the kavalactone , active compounds characteristic of Piper methysticum , better known as kava . Native to the Pacific Islands, this plant is recognized for its natural relaxing and anxiolytic properties , making it a prized ingredient in dietary supplements and nutraceutical preparations .

Kavain analysis allows for the precise quantification of its content in plant extracts, powders, or finished kava-based formulations. This analysis is essential to guarantee quality, safety, and standardization , particularly for quality control and regulatory compliance.

To complete this analysis, it is often recommended to measure the other kavalactones present in kava. Also, explore our total kavalactone analysis for a comprehensive evaluation of the plant's active profile.

Analytical methods: HPLC and LC-MS

The determination of kavain (CAS No. 500-64-1) is carried out using high-precision chromatographic techniques :

• HPLC (high-performance liquid chromatography) : reference method for the separation and quantification of kavalactones in complex matrices.
• LC-MS (liquid chromatography coupled with mass spectrometry) : offers increased specificity and optimal sensitivity , allowing the detection of low concentrations and the distinction between different kavalactones.

These approaches guarantee high reproducibility and reliable quantification of kavain, even in mixtures of natural extracts or multi-active formulations.

Industrial applications

Kavain analysis is primarily aimed at players in the nutraceutical and herbal product , including:

• Manufacturers of dietary supplements based on kava or relaxing plant extracts
• Research laboratories developing new natural ingredients or formulations
• Distributors and brands wishing to verify the compliance of their batches with purity and kavalactone concentration criteria
• Engineering firms and regulatory consultants involved in the qualification of plant-based raw materials

The dosage of kavain thus helps to guarantee the consistency of effectiveness and the safety of use of finished products intended for the European and international market.

For supplement manufacturers, this service can be combined with quality control analyses , such as flavonoid or alkaloid assays , to obtain a complete characterization of the phytochemical profile of plant extracts.

Analyzable materials and matrices

Our partner laboratories perform kavain analysis on a wide variety of matrices:

• Dry or fluid extracts of Piper methysticum
• Standardized vegetable powders
• Capsules, tablets or softgels of dietary supplements
• Hydroalcoholic solutions or macerates

Each analysis is tailored to the type of sample and the level of precision required , according to your technical or regulatory needs.

For complex formulations, a complete characterization of plant actives can also be carried out using infrared spectroscopy (FTIR) or UV-Vis spectrophotometry .

YesWeLab expertise

At YesWeLab , we collaborate with an international network of more than 200 partner laboratories in France, Europe and internationally , selected for their technical expertise and their compliance with quality standards (ISO 17025, COFRAC, GMP, etc.).

Our scientific team supports you at every stage of the process: laboratory selection, analytical method definition, sample tracking, and results validation. Thanks to our intuitive digital platform , you can centralize your analysis requests, compare available options, and track your services with complete transparency.

Since 2020, many manufacturers, distributors and design offices have entrusted us with their analytical needs to ensure the reliability and conformity of their natural products.

Order a Kavain analysis

Do you want to analyze the kavain content in your kava extracts or nutraceutical products?
Submit your request through our platform or contact our scientific team for personalized support . We will identify the most suitable laboratory , based on your matrix, the desired method, and the required level of sensitivity.

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