Grindelic acid dosage

Grindelic acid is a natural compound specific to plants of the genus Grindelia , traditionally used in herbal medicine for their expectorant and respiratory soothing properties. Present mainly in the flowering tops, it is incorporated into preparations intended to relieve coughs, bronchial congestion or inflammatory conditions of the mucous membranes.

Grindelic acid dosage is an essential parameter for ensuring the quality, efficacy, and compliance of extracts used in nutraceutical products or herbal syrups. It ensures reliable standardization of formulations, a key element for manufacturers concerned about the reproducibility and traceability of their finished products.

Analytical methods used

The analysis of grindelic acid is generally carried out by liquid chromatography, depending on the sensitivity requirements and the complexity of the matrix:

• HPLC-DAD (High Performance Liquid Chromatography – Diode Array Detector): reference method for separating and detecting phenolic compounds, triterpenic acids and other plant metabolites. It is suitable for hydroalcoholic extracts, tinctures or syrups based on Grindelia .
• LC-MS (Liquid Chromatography-Mass Spectrometry): allows lower detection limits to be achieved and the structural identity of grindelic acid to be confirmed in complex matrices.

These methods are implemented in specialized laboratories, equipped for the treatment of natural or transformed samples according to current standards (ISO 17025, COFRAC, etc.).

Affected matrices

The dosage of grindelic acid applies to different types of products, at various stages of formulation:

• Grindelia dry extracts : used as active ingredients in food supplements or capsules
• Mother tinctures: traditional forms used in herbal medicine
• Medicinal syrups: for adults or children, for expectorant or decongestant purposes
• Magistral or galenic preparations: in a pharmaceutical framework or in custom formulation

The presence and concentration of grindelic acid may be required in the specifications of manufacturing laboratories, in particular to validate batch conformity or to optimize the claimed therapeutic effects.

Additional analyses available at YesWeLab

YesWeLab offers a wide range of complementary analyses for plant extracts and herbal formulations, allowing in-depth characterization of active ingredients, contaminants and overall quality:

• Dosage of total or specific flavonoids
  → Ex.: vitexin , wogonin , luteolin , quercetin
  These analyses are useful for characterizing the antioxidant and anti-inflammatory effects of extracts associated with Grindelia .
• rosmarinic acid or caffeic acid
  → Compounds sometimes present in synergy in complex extracts for pulmonary use.

These additional analytical services allow manufacturers to secure their formulations, enhance their active ingredients and meet national or European regulatory requirements (e.g.: Novel Food, food supplements, pharmacopoeia, etc.).

Why choose YesWeLab for this analysis?

By entrusting the dosage of your extracts to YesWeLab, you benefit from:

• From a network of specialized laboratories, ISO 17025 certified and COFRAC accredited according to the analyses
• An intuitive digital platform to centralize your requests, quotes and results
• Personalized scientific support to adapt methods to your specifications
• Quick access to more than 300 analyses dedicated to plant extracts, nutraceutical products and natural cosmetics

Need to measure grindelic acid in your extracts or finished products?
Contact our team for a personalized quote or submit your request through our platform.