Goitrin dosage

Goitrin (or oxazolidine-2-thione) is an organosulfur compound derived from the breakdown of glucosinolates, naturally present in plants of the Brassicaceae family (broccoli, cabbage, turnip, mustard, etc.). It is known to interfere with the synthesis of thyroid hormones, particularly by inhibiting the absorption of iodine by the thyroid.

Goitrin testing is essential in several contexts:

• Control of the content of goitrogenic compounds in plant extracts or food supplements based on cruciferous vegetables.
• Assessment of nutritional or functional risks associated with excessive consumption.
• Standardization of plant extracts, in particular to guarantee their safety or regulatory compliance.
• Quality control of formulations intended for sensitive audiences (children, pregnant women, people with thyroid disorders).

Proposed analytical methods

• HPLC-DAD: liquid phase assay with UV detection, suitable for standardized matrices.
• LC-MS/MS: Reference method for trace quantification in complex or enriched matrices. High specificity and sensitivity.

Matrices compatible with the dosage

• Dry or hydroalcoholic extracts of Brassicaceae (cabbage, broccoli, black radish, mustard, etc.)
• Plant powders used in nutraceuticals
• Fortified foods or food supplements
• Functional ingredients for the formulation of health foods

Industrial applications of goitrin assay

• Nutraceutical: control of functional ingredients derived from cruciferous plants.
• Formulation of fortified foods: validation of safety thresholds for sensitive populations.
• Natural cosmetics: evaluation of the composition of plant extracts.
• Regulatory control: monitoring of potentially adverse effects of goitrogens.
• R&D: development of standardized or desulfurized extracts.

Why entrust your analysis to YesWeLab?

YesWeLab rigorously selects its partner laboratories based on their analytical skills and accreditations (ISO 17025, COFRAC, etc.). Our laboratories have state-of-the-art HPLC and LC-MS/MS equipment, guaranteeing reliable, reproducible, and usable results for your formulation, certification, or marketing needs.

Our scientific team supports you every step of the way:

• Choice of extraction and analysis protocols
• Adaptation to specific matrices
• Processing your samples within optimized timeframes
• Provision of complete and standardized analysis reports

Recommended internal links

• Glucosinolate determination : analysis of goitrin precursors in Brassicaceae extracts

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