Goitrine assay

Goitrin (or oxazolidine-2-thione) is an organosulfur compound derived from the breakdown of glucosinolates, naturally present in plants of the Brassicaceae family (broccoli, cabbage, turnip, mustard, etc.). It is known to interfere with the synthesis of thyroid hormones, notably by inhibiting the absorption of iodine by the thyroid.

Goitrin measurement is essential in several contexts:

• Control of goitrogenic compound content in plant extracts or food supplements based on cruciferous vegetables.
• Assessment of nutritional or functional risks associated with excessive consumption.
• Standardization of plant extracts, in particular to guarantee their safety or regulatory compliance.
• Quality control of formulations intended for sensitive audiences (children, pregnant women, people with thyroid disorders).

Proposed analytical methods

• HPLC-DAD: liquid phase assay with UV detection, suitable for standardized matrices.
• LC-MS/MS: reference method for trace quantification in complex or enriched matrices. High specificity and high sensitivity.

Matrices compatible with the dosage

• Dry or hydroalcoholic extracts of Brassicaceae (cabbage, broccoli, black radish, mustard…)
• Plant powders used in nutraceuticals
• Fortified foods or food supplements
• Functional ingredients for health food formulation

Industrial applications of goitrin assay

• Nutraceutical: control of functional ingredients derived from cruciferous plants.
• Formulation of fortified foods: validation of safety thresholds for sensitive populations.
• Natural cosmetics: evaluation of the composition of plant extracts.
• Regulatory control: monitoring of potentially adverse effects of goitrogens.
• R&D: development of standardized or desulfurized extracts.

Why entrust your analysis to YesWeLab?

YesWeLab rigorously selects its partner laboratories based on their analytical expertise and accreditations (ISO 17025, COFRAC, etc.). Our laboratories are equipped with state-of-the-art HPLC and LC-MS/MS equipment, guaranteeing reliable, reproducible, and usable results for your formulation, certification, or commercialization needs.

Our scientific team will support you at every stage:

• Selection of extraction and analysis protocols
• Adaptation to specific matrices
• Your samples will be processed within optimized timeframes
• Provision of complete and standardized analysis reports

Recommended internal links

• Glucosinolate assay : analysis of goitrin precursors in Brassicaceae extracts

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