Ginsenoside Dosage

Ginsenoside assay quantifies the active triterpene saponins characteristic of Panax ginseng , an adaptogenic plant used for centuries for its stimulating and revitalizing properties. These bioactive compounds, called ginsenosides, are the essential analytical markers to ensure the quality, efficacy and conformity of ginseng extracts or supplements.

This analysis has become essential for manufacturers of nutraceutical and phytotherapeutic products, wishing to standardize their extracts and ensure the reproducibility of the physiological effects associated with the plant.

Ginsenosides: markers of activity of Panax ginseng

Ginsenosides are triterpene glycosides belonging to the saponin family. There are more than thirty of them, among which the most studied are Rb1 , Rg1 , Re , Rc , Rd , Rh1 and Rg3 . Each has specific biological activities: improving resistance to stress, stimulating the immune system, cognitive support, modulation of energy metabolism or cellular protection.

The composition of ginsenosides varies according to the species (Panax ginseng, Panax quinquefolius, Panax notoginseng), the part of the plant used (root, leaf, stem) and the processing conditions (white or red ginseng). The dosage of these molecules makes it possible to authenticate the botanical origin, to evaluate the potency of the extracts and to control their conformity with the expected specifications.

Objectives of ginsenoside dosage

The dosage of ginsenoside meets several analytical and regulatory objectives:

• control the total ginsenoside content in ginseng extracts or powders,
• identify and quantify the main marker ginsenosides (Rb1, Rg1, Re, etc.),
• check the conformity of products with pharmacopoeial monographs,
• assess the stability of extracts during storage or processing,
• validate health claims or functional claims of food supplements.

This analysis also makes it possible to compare the composition of different types of extracts (hydroalcoholic, aqueous, standardized) and to guarantee the consistency of the batches used in nutraceutical formulations.

Analytical methods used

The dosage of ginsenosides is based on high-performance chromatographic methods:

• HPLC (high-performance liquid chromatography) : allows the separation and individual quantification of ginsenosides from a purified extract. This method is the most widely used for routine quality control.
• LC-MS (liquid chromatography coupled with mass spectrometry) : offers increased sensitivity and precise structural identification of different ginsenosides, including those present at very low concentrations.

These techniques can be combined with complementary analyses such as the dosage of Indian ginseng (ashwagandha), the dosage of rhodiola, or even the dosage of bacopa monnieri, in order to compare several adaptogenic extracts on a chemical and functional level.

Sectors and applications of ginsenoside dosage

Ginsenoside analysis is particularly requested in:

• the nutraceutical industry , for the formulation of supplements intended for vitality, physical performance or memory,
• phytotherapy , for the control of plant extracts used in magistral preparations and herbal products,
• scientific research , for the chemical characterization of new varieties of ginseng or for monitoring the transformation of white ginseng into red ginseng,
• quality control of plant raw materials , in order to guarantee the conformity of imported batches to purity and concentration standards.

Ginsenoside analysis can be complemented by other services available on the YesWeLab platform, such as total polyphenol assays, flavonoid assays , or alkaloid assays. These analyses allow us to characterize the overall phytochemical profile of an extract and better understand its biological effects.

Carrying out analyses at YesWeLab

YesWeLab entrusts the measurement of ginsenosides to partner laboratories with expertise in liquid chromatography and phytochemical analysis. These laboratories have the latest generation of HPLC and LC-MS equipment and are mostly certified or accredited according to the ISO 17025 standard and the COFRAC standard.

The YesWeLab scientific team will help you choose the method best suited to your needs: global or selective dosage, identification of Rb1 and Rg1 markers, quality control of raw materials or validation of finished formulations.

Thanks to the YesWeLab digital platform, manufacturers, formulators, and distributors can centralize their analyses, track their samples in real time, and access results reports online. This approach guarantees complete traceability, optimal responsiveness, and analytical quality that meets regulatory requirements.

Since 2020, YesWeLab has supported numerous players in nutraceuticals, natural health and phytotherapy in their analytical control needs, enabling them to accelerate the marketing of reliable, standardized and compliant products.

Technical data

• CAS No.: 74749-74-9
• Methods: HPLC, LC-MS
• Expertise: Physicochemical, nutritional
• Sectors of activity: Nutraceuticals, plants
• Main compounds: ginsenosides Rb1, Rg1, Re, Rc, Rd, Rh1, Rg3

For any specific request, contact our team to obtain a personalized quote and analytical advice tailored to your ginseng samples.