Ginsenoside dosage

Ginsenoside analysis quantifies the active triterpene saponins characteristic of Panax ginseng , an adaptogenic plant used for centuries for its stimulating and revitalizing properties. These bioactive compounds, called ginsenosides, are essential analytical markers for ensuring the quality, efficacy, and compliance of ginseng extracts or supplements.

This analysis has become indispensable for manufacturers of nutraceutical and phytotherapeutic products, wishing to standardize their extracts and ensure the reproducibility of the physiological effects associated with the plant.

Ginsenosides: markers of activity in Panax ginseng

Ginsenosides are triterpene glycosides belonging to the saponin family. More than thirty have been identified, among which the most studied are Rb1 , Rg1 , Re , Rc , Rd , Rh1 and Rg3 . Each exhibits specific biological activities: improved stress resistance, immune system stimulation, cognitive support, modulation of energy metabolism, and cell protection.

The ginsenoside composition varies depending on the species (Panax ginseng, Panax quinquefolius, Panax notoginseng), the part of the plant used (root, leaf, stem), and the processing conditions (white or red ginseng). Measuring these molecules allows for authentication of the botanical origin, evaluation of the potency of the extracts, and verification of their compliance with expected specifications.

Objectives of ginsenoside assay

Ginsenoside measurement serves several analytical and regulatory purposes:

• to control the total ginsenoside content in ginseng extracts or powders,
• identify and quantify the main marker ginsenosides (Rb1, Rg1, Re, etc.),
• verify the conformity of the products with the pharmacopoeia monographs,
• to assess the stability of extracts during storage or processing,
• validate the health claims or functional claims of food supplements.

This analysis also makes it possible to compare the composition of different types of extracts (hydroalcoholic, aqueous, standardized) and to guarantee the consistency of the batches used in nutraceutical formulations.

Analytical methods used

Ginsenoside analysis relies on high-performance chromatographic methods:

• HPLC (high-performance liquid chromatography) : allows the separation and individual quantification of ginsenosides from a purified extract. This method is the most widely used for routine quality control.
• LC-MS (liquid chromatography coupled with mass spectrometry) : offers increased sensitivity and precise structural identification of different ginsenosides, including those present at very low concentrations.

These techniques can be combined with complementary analyses such as the dosage of Indian ginseng (ashwagandha), the dosage of rhodiola, or the dosage of bacopa monnieri, in order to compare several adaptogenic extracts on a chemical and functional level.

Sectors and applications of ginsenoside assay

Ginsenoside analysis is particularly requested in:

• the nutraceutical industry , for the formulation of supplements intended for vitality, physical performance or memory,
• phytotherapy , for the control of plant extracts used in compounded preparations and herbal products,
• scientific research , for the chemical characterization of new varieties of ginseng or for monitoring the transformation of white ginseng into red ginseng,
• quality control of plant raw materials , in order to guarantee the conformity of imported batches to purity and concentration standards.

Ginsenoside analysis can be complemented by other services available on the YesWeLab platform, such as total polyphenol, flavonoid , or alkaloid analysis. These analyses allow for the characterization of an extract's overall phytochemical profile and a better understanding of its biological effects .

Analysis performed at YesWeLab

YesWeLab entrusts the quantification of ginsenosides to partner laboratories specializing in liquid chromatography and phytochemical analysis. These laboratories are equipped with state-of-the-art HPLC and LC-MS equipment and are mostly certified or accredited according to ISO 17025 and the COFRAC standard.

The YesWeLab scientific team assists you in choosing the method best suited to your needs: global or selective assay, identification of Rb1 and Rg1 markers, quality control of raw materials or validation of finished formulations.

Thanks to the YesWeLab digital platform, manufacturers, formulators, and distributors can centralize their analyses, track their samples in real time, and access results reports online. This approach guarantees complete traceability, optimal responsiveness, and analytical quality that meets regulatory requirements.

Since 2020, YesWeLab has been supporting many players in nutraceuticals, natural health and phytotherapy in their analytical control needs, enabling them to accelerate the marketing of reliable, standardized and compliant products.

Technical data

• CAS No.: 74749-74-9
• Methods: HPLC, LC-MS
• Expertise: Physico-chemical, nutritional
• Business sectors: Nutraceuticals, plants
• Main compounds: ginsenosides Rb1, Rg1, Re, Rc, Rd, Rh1, Rg3

For any specific request, contact our team to obtain a personalized quote and analytical advice tailored to your ginseng samples.