Fraxin (coumarin) dosage

Fraxin is a heteroside belonging to the coumarin family, primarily found in the bark and leaves of the ash tree (Fraxinus excelsior and related species). This natural molecule is studied in the field of phytotherapy, where it serves as a quality marker for standardized plant extracts. Its laboratory analysis is essential to guarantee the conformity, safety, and efficacy of plant-based products intended for the nutraceutical and pharmaceutical sectors.

Fraxin is identified by CAS number 524-30-1 and is distinguished by its biological properties, notably its role in the antioxidant and protective activity of ash extracts. Controlling its content in plant-based preparations is therefore essential to ensure a homogeneous formulation that complies with regulatory requirements.

Analytical methods for the determination of fraxin

Fraxin assay relies on chromatographic techniques, allowing precise and reliable quantification even in complex matrices such as plant extracts.

High-performance liquid chromatography (HPLC) is the reference method for the separation and quantification of coumarins. It allows for excellent resolution and reproducible measurement of fraxin, even at low concentrations.

Liquid chromatography coupled with mass spectrometry (LC-MS) is a recommended complementary method for confirming the molecular identity of fraxin and simultaneously detecting other bioactive compounds. These analytical techniques ensure selective detection and precision suitable for industrial requirements, particularly for extract standardization and compliance with specifications.

Affected matrices

Fraxin dosage applies to various matrices derived from medicinal plants and food supplements, such as:

• • Standardized plant extracts
  • Ash leaf infusions
  • Plant powders used in nutraceuticals
  • Complex preparations incorporating several natural active ingredients

The determination of fraxin is recommended as part of the quality control of raw materials and finished products, in order to ensure consistency and conformity.

The importance of dosage for manufacturers

In the nutraceutical, phytotherapy, and nutrition sectors, extract standardization is a key step in ensuring product efficacy and safety. The presence and concentration of fraxin serve as quality criteria, enabling manufacturers and distributors to ensure regulatory compliance, manage the natural variability of raw materials, scientifically validate their products, and guarantee traceability for consumers.

Fraxin dosage is therefore part of a comprehensive approach to quality control and responsible marketing of natural health products.

Additional analyses available

In addition to fraxin, other bioactive compounds from the coumarin and flavonoid families can be analyzed for a complete characterization of plant extracts. YesWeLab offers, in particular:

Esculin (coumarin) assay,
rutin (flavonoid) assay,
quercetin (flavonoid) assay,
hyperoside (flavonoid) assay

These services make it possible to obtain a complete analytical profile of plant extracts, strengthening the standardization and differentiation of products on the market.

YesWeLab expertise

YesWeLab relies on a rigorously selected network of partner laboratories, the majority of which are ISO 17025 and COFRAC certified and accredited. Each analysis is entrusted to the most suitable laboratory based on the matrix to be tested, the required method, and each client's regulatory constraints.

Since 2020, the YesWeLab digital platform has enabled manufacturers, distributors and design offices to centralize their analytical needs, simplify sample management and receive reliable results as quickly as possible.

The scientific team supports each project with precision and responsiveness, in order to meet the specific requirements of each specification.