Estradiol dosage

Estradiol is a steroid hormone belonging to the estrogen family. Although primarily associated with animal and human physiology, it is sometimes found in trace amounts in certain plants or natural substances. Its presence may be linked to potential hormonal effects, thus justifying its analytical monitoring in various contexts. In the nutraceutical and phytotherapeutic industries, estradiol measurement is particularly relevant to ensure the safe use of plant extracts and to assess potential endocrine effects.

Analytical techniques used:
Estradiol measurement requires very high sensitivity because it is often present at very low concentrations. The analysis is performed by high-performance liquid chromatography (HPLC) coupled with mass spectrometry (LC-MS or LC-MS/MS). This approach guarantees:

• high specificity for differentiating estradiol from other estrogens or metabolites,
• precise quantification even in complex matrices,
• reliable detection at trace levels.

The use of LC-MS/MS also makes it possible to eliminate interferences from other natural compounds and to obtain a complete analytical profile.

Industrial and regulatory applications:
Estradiol measurement is applicable to several sectors:

• Nutraceuticals : quality control of food supplements and herbal preparations.
• Phytotherapy : evaluation of the safety of plant extracts used for their functional effects.
• Cosmetics : verification of the absence or presence in trace amounts of hormones in natural formulations.
• Natural products of animal origin : monitoring of hormone levels in certain raw materials.

From a regulatory standpoint, estradiol determination may be required in compliance and health safety studies, particularly to ensure the absence of undesirable hormonal effects.

Matrices analyzed:
The analyses are performed on different types of samples:

• plant extracts (medicinal plants, natural preparations),
• powders and food supplements,
• complex natural products
• non-medicinal animal substances.

Scientific interest and quality control:
Estradiol quantification is of major interest for scientific research and the development of innovative products. In particular, it allows for:

• to better understand the interactions between phytohormones and metabolites,
• to assess the stability and purity of natural extracts,
• to anticipate potential regulatory issues related to endocrine effects.

By integrating this type of analysis into their quality control strategy, manufacturers strengthen the safety of their products and meet the growing expectations of consumers in terms of transparency and traceability.

YesWeLab, your analytical partner.
At YesWeLab, we collaborate with a rigorously selected network of accredited and certified partner laboratories (ISO 17025, COFRAC, etc.) to guarantee reliable results that comply with international standards. Our experts support professionals in the nutraceutical, herbal, and natural products sectors in choosing the analytical methods best suited to their needs.

Our digital platform allows you to centralize your requests, track your samples and receive your results as quickly as possible.

Further analyses:
Estradiol measurement can be combined with other analyses of bioactive molecules for a comprehensive monitoring of plant extracts:

• Flavonoid dosage

These additional analyses strengthen quality control and allow for better characterization of natural matrices.

Entrust your analyses to YesWeLab.
Since 2020, numerous manufacturers, distributors, and engineering firms have relied on YesWeLab to manage their analyses. Our scientific team is committed to meeting your specific needs with precision, responsiveness, and transparency.

To learn more or submit a specific need regarding estradiol testing, contact our team now and get a personalized quote.