Efficacy studies

Efficacy studies aim to scientifically demonstrate the claimed effects of a product or active ingredient . They constitute a key step in validating the cosmetic, nutraceutical, or phytotherapeutic performance before they are placed on the market.

These studies make it possible to objectively quantify the advertised benefits — such as hydration, anti-aging effect, soothing action, firmness, tone or satiety — using standardized analytical, clinical or instrumental methods.

They are essential to support a marketing claim , in accordance with the requirements of Regulation (EC) No 1223/2009 for cosmetics and European regulations on nutrition and health claims (EC No 1924/2006) for food supplements.

Analytical methodologies

Efficacy studies can be conducted using several complementary approaches:

1. In vitro studies

• Performed on cell cultures, reconstituted tissues or biomimetic models.
• They allow us to evaluate specific biological mechanisms : antioxidant activity, collagen stimulation, elastase inhibition, anti-inflammatory effects, etc.
• Associated methods: enzyme assay, RT-qPCR (gene expression), immunolabeling, spectrophotometry, HPLC, etc.

2. Ex vivo studies

• Performed on isolated human or animal tissues (skin, mucous membranes, plant organs).
• Used to observe direct structural or biochemical effects after application of the product.
• Methods: histology, electron microscopy, chromatography, targeted biochemical measurements.

3. In vivo studies

Conducted on human volunteers or animal models, in accordance with applicable regulations.

They allow us to measure the overall and perceived effect of the product under real-world conditions of use .

Instrumental methods used:

• Corneometry : measurement of skin hydration.
• Cutometry : assessment of elasticity and firmness.
• Colorimetry : measurement of skin pigmentation and radiance.
• 3D profilometry : quantification of wrinkles and skin texture.
• Sensory analysis and consumer questionnaires.

Products and matrices concerned

Efficacy studies apply to a wide range of products:

• Cosmetics : creams, serums, hair care, sun care, anti-aging, soothing, moisturizing products.
• Active ingredients : plant extracts, peptides, vitamins, antioxidants.
• Dietary supplements : slimming, energizing, cognitive or immune formulas.
• Natural products : essential oils, botanical extracts, phyto-active complexes.

Industrial and regulatory applications

Efficacy studies are essential for:

• To scientifically support marketing claims (“hydrates the skin”, “improves firmness”, “promotes satiety”…).
• Compile the regulatory file for the product (cosmetic, food, medical device).
• Optimize the formulation by validating the synergy of the active ingredients.
• Compare the performance of several versions of the same product.

They guarantee the transparency and credibility of claims , strengthening the confidence of consumers and authorities.

Related analyses

YesWeLab recommends combining efficacy studies with other complementary tests for a comprehensive approach:

• Hydration test to quantify the hydrating effectiveness of a product.
• Skin sensitivity test to check product tolerance.
• Study of the photostability of a sunscreen product to evaluate its stability under UV light.
• Stability test to confirm the product's durability over time.
• Measuring collagen and elastin levels to correlate the anti-aging effect with structural biomarkers.

YesWeLab's expertise

YesWeLab provides a network of laboratories specializing in cosmetic and nutraceutical efficacy studies , accredited to ISO 17025 and COFRAC .

Thanks to the YesWeLab digital platform , you can:

• Centralize your tests and analyses,
• Follow your studies online,
• Obtain your reports in full compliance with regulatory requirements.