Efficacy studies

Efficacy studies aim to scientifically demonstrate the claimed effects of a product or active ingredient . They constitute a key step in validating cosmetic, nutraceutical or phytotherapeutic performance before they are placed on the market.

These studies make it possible to objectively quantify the announced benefits — such as hydration, anti-aging effect, soothing action, firmness, tone or satiety — using standardized analytical, clinical or instrumental methods.

They are essential to support a marketing claim , in accordance with the requirements of Regulation (EC) No. 1223/2009 for cosmetics and European regulations on nutrition and health claims (EC No. 1924/2006) for food supplements.

Analytical methodologies

Efficacy studies can be conducted using several complementary approaches:

1. In vitro studies

• Carried out on cell cultures, reconstituted tissues or biomimetic models.
• Allows the evaluation of specific biological mechanisms : antioxidant activity, collagen stimulation, elastase inhibition, anti-inflammatory effects, etc.
• Associated methods: enzymatic assay, RT-qPCR (gene expression), immunolabeling, spectrophotometry, HPLC, etc.

2. Ex vivo studies

• Performed on isolated human or animal tissues (skin, mucous membranes, plant organs).
• Used to observe direct structural or biochemical effects after application of the product.
• Methods: histology, electron microscopy, chromatography, targeted biochemical measurements.

3. In vivo studies

Carried out on human volunteers or animal models, according to applicable regulations.

Allows the overall and perceived effect of the product to be measured under real conditions of use .

Instrumental methods used:

• Corneometry : measurement of skin hydration.
• Cutometry : assessment of elasticity and firmness.
• Colorimetry : measurement of skin pigmentation and radiance.
• 3D profilometry : quantification of wrinkles and skin texture.
• Sensory analysis and consumer questionnaires.

Products and matrices concerned

Efficacy studies apply to a wide range of products:

• Cosmetics : creams, serums, hair care, sunscreens, anti-aging, soothing, moisturizing.
• Active ingredients : plant extracts, peptides, vitamins, antioxidants.
• Food supplements : slimming, energizing, cognitive or immune formulas.
• Natural products : essential oils, botanical extracts, phyto-active complexes.

Industrial and regulatory applications

Efficacy studies are essential for:

• Scientifically support marketing claims (“hydrates the skin”, “improves firmness”, “promotes satiety”…).
• Prepare the regulatory file for the product (cosmetic, food, medical device).
• Optimize the formulation by validating the synergy of the active ingredients.
• Compare the performance of multiple versions of the same product.

They guarantee the transparency and credibility of claims , strengthening the confidence of consumers and authorities.

Related analyses

YesWeLab recommends combining efficacy studies with other complementary tests for a comprehensive approach:

• Hydration test to quantify the hydrating effectiveness of a treatment.
• Skin sensitivity test to check product tolerance.
• Study of the photostability of a sunscreen product to assess stability under UV.
• Stability test to confirm the durability of the product over time.
• Collagen and elastin to correlate anti-aging effect with structural biomarkers .

YesWeLab expertise

YesWeLab provides a network of laboratories specialized in cosmetic and nutraceutical efficacy studies , ISO 17025 and COFRAC .

Thanks to the YesWeLab digital platform , you can:

• Centralize your tests and analyses,
• Follow your studies online,
• Get your reports complete and compliant with regulatory requirements.