Palmatine (benzylisoquinoline alkaloid) dosage

The palmatin assay allows for the quantification of this natural alkaloid from the benzylisoquinoline family, structurally similar to berberine. It is found primarily in Asian medicinal plants such as Coptis chinensis , Berberis aristata , Phellodendron amurense , and Tinospora cordifolia .

Palmatin is studied for its antimicrobial, antioxidant, anti-inflammatory, and sedative properties . It is used in dietary supplements and herbal preparations for its potential role in maintaining metabolic and nervous system well-being .

Accurate palmatin dosage is essential to ensure the quality, safety and regulatory compliance of nutraceutical extracts and products.

Analytical principles and techniques

The analysis of palmatin relies on high-precision chromatographic methods, primarily:

• HPLC-DAD (high-performance liquid chromatography with UV-visible detection) : a standardized method allowing the reliable separation and quantification of palmatin, often in parallel with berberine and jatrorrhizin.
• LC-MS / LC-MS/MS (liquid chromatography coupled with mass spectrometry) : a more sensitive and specific technique, used to confirm the identity of the molecule and detect traces in complex matrices.

These techniques guarantee complete traceability of active compounds and precise quantification , even in mixtures containing several related alkaloids.

Analyzed matrices

The assay of palmatin is applicable to a wide variety of matrices:

• Dry and hydroalcoholic extracts of medicinal plants,
• Mother tinctures and concentrated solutions,
• Dietary supplements (capsules, tablets, vegetable powders),
• Combined nutraceutical formulations (mixtures of alkaloids, polyphenols, flavonoids).

This analysis is often associated with the determination of other alkaloids of the same family to draw up the complete phytochemical profile of an extract.

Analytical and regulatory interest

Palmatin measurement serves several purposes:

• Quality control of plant extracts and finished products,
• Standardization of raw materials according to reference levels,
• Regulatory compliance verification (food supplements, pharmacopoeias),
• Detection of additives or impurities in finished products,
• Study of the stability and behavior of alkaloids during storage.

In the context of Regulation (EU) No 2015/2283 on novel foods, the control of alkaloid levels is also a matter of toxicological safety and traceability .

Industrial applications

Palmatin analysis is particularly useful in:

• Nutraceuticals , for the formulation of supplements with metabolic, antioxidant or neuroprotective effects,
• Phytotherapy , for the validation of natural extracts from Asian plants,
• Cosmetics , for formulations based on purified plant extracts,
• Pharmaceutical research , in the study of the pharmacological effects of natural alkaloids.

Further analyses recommended

For a complete characterization of plant alkaloids and the phytochemical profile of an extract, YesWeLab recommends:

• Berberine (benzylisoquinoline alkaloid) dosage
• Total flavonoid content determination by HPLC
• Analysis of polyphenols by LC-MS
• Dosage of curcumin (curcuminoids)

These additional analyses allow for a complete characterization of the bioactive spectrum of a plant extract and better control of product quality.

YesWeLab Expertise

At YesWeLab, we entrust the analysis of palmatin to partner laboratories accredited to ISO 17025 and COFRAC , experts in analytical chemistry and phytochemistry.
Our specialists assist you in choosing analytical methods , validating regulatory compliance , and standardizing your plant extracts .

Thanks to the YesWeLab digital platform , you can centralize the management of your analyses , from the quote to the receipt of results, with personalized scientific monitoring .