Dosage of sesquiterpene coumarins

Sesquiterpene coumarins are bioactive compounds of plant origin belonging to the aromatic lactone family. They are particularly studied for their anti-inflammatory, antioxidant, and antimicrobial properties. Found in various medicinal and aromatic plants, they are used in both nutraceuticals and cosmetics for their protective and regenerative effects. Their precise dosage is essential to ensure the standardization of plant extracts and guarantee the traceability of industrial formulations.

Analytical methods for the determination of sesquiterpene coumarins

The determination of sesquiterpene coumarins relies on high-performance chromatographic methods allowing for precise and reproducible quantification.

• HPLC (High Performance Liquid Chromatography) : reference method for the separation and quantification of coumarins in plant extracts and finished products.
• LC-MS (Liquid Chromatography coupled with Mass Spectrometry) : a more sensitive technique, suitable for complex matrices and allowing specific identification of each molecule present, even at very low concentrations.

These approaches are in line with analyses carried out on other bioactive plant compounds such as theanine , theobromine or trigonelline .

Industrial applications and sectors concerned

Measuring sesquiterpene coumarins is particularly useful in several areas:

• Nutraceuticals : standardization of medicinal plant extracts and formulation of food supplements targeting circulatory health, oxidative stress or chronic inflammation.
• Cosmetics : integration into anti-aging, repairing or protective formulations thanks to their antioxidant and regenerating effects.
• Research and development : identification of new bioactive molecules and evaluation of their therapeutic potential.
• Phytotherapy : securing and traceability of raw extracts used in traditional preparations.

This analysis complements those of other coumarin families, such as fraxin , while fitting into a broader framework of valorizing plant assets.

Matrices analyzed for sesquiterpene coumarins

Analyses can be performed on a wide variety of matrices: crude or standardized plant extracts, essential oils and lipid extracts, medicinal plant powders, nutraceutical capsules and tablets, and complex cosmetic formulations. The analytical methodology is adjusted according to the matrix to ensure the reliability of the results and regulatory compliance.

Challenges of standardization and traceability

The content of sesquiterpene coumarins can vary considerably depending on the plant species, geographical origin, growing conditions, and extraction methods. Laboratory analysis of these coumarins allows for: verification of the actual concentration of claimed active ingredients, ensuring consistency between different production batches, guaranteeing regulatory compliance, and strengthening the scientific credibility of health and cosmetic claims. These issues are similar to those encountered for other bioactive compounds such as tyramine or tryptamine .

YesWeLab's expertise in the measurement of sesquiterpene coumarins

YesWeLab collaborates with a network of over 200 partner laboratories in France and Europe, selected for their expertise and accreditations (ISO 17025, COFRAC, etc.). Our scientific team assists you in selecting the method best suited to your samples and objectives. Thanks to our digital platform, you benefit from a comprehensive service: online quote requests, sample tracking, and results delivered within optimized timeframes. Since 2020, numerous manufacturers, distributors, and engineering firms have entrusted us with their analyses to ensure the safety and value of their products.

Take action

Do you want to guarantee the quality and compliance of your plant extracts or nutraceutical and cosmetic formulations? Entrust your samples to YesWeLab for reliable and precise analysis of sesquiterpene coumarins. Request a quote online now for your analysis.