Dosage of sesquiterpene coumarins

Sesquiterpene coumarins are bioactive compounds of plant origin belonging to the aromatic lactone family. They are particularly studied for their anti-inflammatory, antioxidant, and antimicrobial properties. Present in various medicinal and aromatic plants, they are used in both nutraceuticals and cosmetics for their protective and regenerative effects. Their dosage is essential to ensure the standardization of plant extracts and guarantee the traceability of industrial formulations.

Analytical methods for the determination of sesquiterpene coumarins

The determination of sesquiterpene coumarins is based on high-performance chromatographic methods allowing precise and reproducible quantification.

• HPLC (High Performance Liquid Chromatography) : reference method for the separation and quantification of coumarins in plant extracts and finished products.
• LC-MS (Liquid Chromatography coupled with Mass Spectrometry) : more sensitive technique, suitable for complex matrices and allowing specific identification of each molecule present, even at very low concentrations.

These approaches are in line with analyses carried out on other bioactive plant compounds such as theanine , theobromine or trigonelline .

Industrial applications and sectors concerned

The dosage of sesquiterpene coumarins is particularly useful in several areas:

• Nutraceuticals : standardization of medicinal plant extracts and formulation of food supplements targeting circulatory health, oxidative stress or chronic inflammation.
• Cosmetics : integration into anti-aging, restorative or protective formulations thanks to their antioxidant and regenerating effects.
• Research and development : identification of new bioactive molecules and evaluation of their therapeutic potential.
• Phytotherapy : security and traceability of raw extracts used in traditional preparations.

This analysis complements those of other families of coumarins, such as fraxin , while fitting into a broader framework of valorization of plant active ingredients.

Matrices analyzed for sesquiterpene coumarins

Analyses can be performed on a wide variety of matrices: crude or standardized plant extracts, essential oils and lipid extracts, medicinal plant powders, nutraceutical capsules and tablets, complex cosmetic formulations. The analytical methodology is adjusted according to the matrix to ensure reliable results and regulatory compliance.

Challenges of standardization and traceability

The content of sesquiterpene coumarins can vary considerably depending on the plant species, geographical origin, growing conditions and extraction processes. Their laboratory measurement makes it possible to: verify the actual concentration of active ingredients claimed, ensure consistency between different production batches, guarantee regulatory compliance and strengthen the scientific credibility of health and cosmetic claims. These challenges are similar to those encountered for other bioactive compounds such as tyramine or tryptamine .

YesWeLab's expertise in the dosage of sesquiterpene coumarins

YesWeLab collaborates with a network of more than 200 partner laboratories in France and Europe, selected for their expertise and accreditations (ISO 17025, COFRAC, etc.). Our scientific team assists you in selecting the method best suited to your samples and objectives. Thanks to our digital platform, you benefit from a complete service: online quote requests, sample tracking, and timely delivery of results. Since 2020, numerous manufacturers, distributors, and design offices have entrusted us with their analyses to secure and enhance the value of their products.

Take action

Do you want to guarantee the quality and compliance of your plant extracts or nutraceutical and cosmetic formulations? Entrust your samples to YesWeLab for reliable and accurate sesquiterpene coumarin assays. Request a quote online now for your analysis.