EDTA (ethylenediaminetetraacetic acid) determination

What is EDTA?

EDTA (ethylenediaminetetraacetic acid) is a chelating agent widely used in cosmetic, food, pharmaceutical, and industrial formulations. Its main function is to complex metal ions, thus preventing their catalytic, oxidative, or precipitating action. This helps extend product stability, enhance the action of preservatives, or optimize industrial processes sensitive to trace metals.

It is found in shampoos, creams, disinfectants, dietary supplements, cleaning products, and water treatments. In the form of free acid or salts (Na₂EDTA, CaNa₂EDTA, etc.), its presence is strictly regulated depending on the sectors of application.

Why measure EDTA?

EDTA dosage is essential for:

• Check compliance with formulation specifications
• Respect regulatory limits according to uses (e.g.: cosmetics, food)
• Control the quality of raw materials and finished products
• Validate the effectiveness of the product from a technological or preservative point of view
• Document authorization or registration files (SDS, CPNP, REACH)

Certain regulations impose maximum permitted levels, particularly in cosmetics (EC regulation no. 1223/2009) or in certain food uses, where EDTA is listed as an additive (E385) under conditions.

Which matrices are affected?

EDTA dosage applies to a wide variety of industrial and commercial products:

• Cosmetic formulations: creams, gels, hair care, cleansers
• Food products: sauces, preserves, drinks, supplements
• Pharmaceutical products or medical devices
• Disinfectants, cleaning solutions, detergent products
• Process or treatment water (particularly in the textile or chemical industry)

Analytical methods for the determination of EDTA

Several reliable analytical methods can quantify EDTA depending on the nature of the matrix:

• Complexometric titration (with the Mg²⁺ or Ca²⁺ ion): classical method adapted to simple solutions
• HPLC (high performance liquid chromatography): allows efficient separation even in complex formulations
• UV-Visible spectrophotometry: after derivatization or color complexation, suitable for low concentration products
• Methods validated according to ISO, USP, or internal standards according to ISO 17025

The choice of method depends on the type of sample, the required precision, the regulatory thresholds and the context of use.

YesWeLab: Your Partner for EDTA Analysis

At YesWeLab , we connect you with laboratories that are experts in fine chemical analyses and capable of measuring EDTA in simple or complex matrices. Our partners are ISO 17025 certified and often COFRAC accredited, ensuring a high level of expertise and complete traceability of results.

We support you for:

• Define the analytical method best suited to your needs
• Guarantee regulatory compliance of your finished products or raw materials
• Obtain usable analysis reports for auditing or regulation
• Benefit from personalized monitoring provided by our scientific team

Our secure digital platform allows you to centralize all your analyses, track your projects in real time, and view your results at any time.

Need a reliable and standardized EDTA dosage?

YesWeLab supports you in the quality, regulatory, and technical control of your EDTA-containing formulations.
Contact our team today for a quote or to discuss your specific chemical analysis needs.