Frangulin A, frangulin B dosage

Frangulins are anthraquinone glycosides naturally present in buckthorn bark (Rhamnus frangula). They are essential chemical markers in the evaluation of the quality and efficacy of buckthorn extracts, traditionally used as mild laxatives in herbal medicine.

Their laboratory dosage helps guarantee regulatory compliance, the standardization of plant extracts and control of the content of active ingredients, in order to ensure both the safety and efficacy of finished products.

Importance of frangulin dosage

Frangulin analysis is of major importance to the herbal medicine, nutraceutical, and dietary supplement industries. These molecules are responsible for the biological activity sought in buckthorn preparations.

Accurate dosage is necessary for:

• control the active content and standardize the extracts
• ensure compliance with the pharmacopoeia and regulatory recommendations
• ensure safety of use by avoiding overdoses
• scientifically enhance buckthorn extracts intended for the nutraceutical market

The quantitative determination of frangulins is therefore a central element of quality control in the production chain of plant extracts.

Available analytical methods

The dosage of frangulins is based on high-precision chromatographic techniques:

• HPLC-DAD (high performance liquid chromatography with diode array detection), which enables fine separation and reliable quantification of anthraquinones in complex matrices.
• LC-MS (liquid chromatography coupled with mass spectrometry), which offers enhanced sensitivity and specificity to confirm the molecular identity of frangulins and simultaneously detect other anthraquinones present in buckthorn.

These analytical techniques are suitable for both raw materials and finished products, guaranteeing complete traceability and optimal reliability of results.

Analyzed matrices

Frangulin analyses mainly concern:

• standardized plant extracts of buckthorn
• powders from the dried bark
• buckthorn-based preparations used in phytotherapy and nutraceuticals

The dosage can be carried out both in simple products and in complex formulations containing several plants.

Industrial applications

Assessing frangulin content is essential for manufacturers of dietary supplements and herbal products. It supports marketing with reliable analytical data that meets regulatory expectations.

This analysis also meets the needs of distributors and design offices responsible for verifying batch quality, assessing product stability and meeting the requirements of health authorities.

Additional analyses available

For a complete characterization of plant extracts, YesWeLab offers other assays for anthraquinone and flavonoid compounds. Among the analyses available in our catalog:

Emodin (anthraquinone) dosage
Aloin (anthraquinone) dosage
Chrysophanol (anthraquinone) dosage
Quercetin (flavonoid) dosage
Rutin (flavonoid) dosage

These services help to complete the analytical profile of plant extracts, optimize standardization and strengthen the scientific value of products on the market.

YesWeLab expertise

YesWeLab provides its network of carefully selected partner laboratories, most of which are ISO 17025 and COFRAC certified and accredited. Each project is assigned to the most suitable laboratory based on the matrix, the required method, and regulatory requirements.

Since 2020, our digital platform has simplified analysis management for many manufacturers and distributors. It allows for centralized requests, real-time tracking, and fast, reliable results.

Our scientific team supports each client with responsiveness and precision, in order to meet specific needs in terms of quality control and regulations.