Diosmetin (flavone) dosage

Diosmetin is a methoxylated flavone belonging to the large family of flavonoids. Naturally present in certain citrus fruits (such as orange or lemon) and in several medicinal plants, it plays a major role in formulations with vasoprotective, antioxidant or anti-inflammatory properties. It is also the main active metabolite of diosmin , a molecule well known for its beneficial effects on microcirculation and venous tone.

In the context of developing food supplements based on citrus extracts or specific flavonoids, the dosage of diosmetin allows:

• To standardize plant extracts
• To control the quality of raw materials
• To evaluate the enzymatic or metabolic transformation of diosmin
• To validate functional or nutritional claims
• To secure the efficiency and traceability of finished products

Available analytical methods

The analysis of diosmetin can be carried out using several chromatographic techniques depending on the required precision and the matrix analyzed:

• High-performance liquid chromatography (HPLC or UPLC) : with UV detection at 330 nm or by mass spectrometry (LC-MS), this method is particularly suitable for complex extracts or concentrated matrices.
• Gas chromatography (GC-MS) : used after derivatization, particularly for volatile matrices or purified extracts, it provides excellent specificity and trace detection.

YesWeLab's partner laboratories adapt the method to the type of sample (plant powders, capsules, hydroalcoholic extracts, juices or liquid formulations) and to your analytical objectives (quality, compliance, research and development).

Frequently analyzed matrices

• Citrus extracts (Citrus sinensis, Citrus aurantium)
• Raw materials for food supplements
• Products enriched with flavonoids or diosmin
• Plant powders, dry or fluid extracts
• Functional ingredients for circulatory formulations

Industrial applications

Diosmetin dosage is a key tool in:

• Standardization of botanical extracts for vascular health
• Evaluation of the metabolic transformation of diosmin in vitro or in vivo
• The development of nutraceutical products based on the synergistic action of flavonoids
• Quality control of active ingredients in capsule, tablet or oral solution formulations
• Bioavailability and efficacy studies conducted by R&D laboratories

Why choose YesWeLab?

YesWeLab supports you in the detailed analysis of phytochemical compounds such as diosmetin thanks to a network of highly specialized laboratories, rigorously selected for their expertise, their regulatory compliance (ISO 17025, COFRAC, etc.) and their ability to adapt to your needs.

Thanks to our digital platform, you benefit from centralized and simplified management of your analyses:

• Sending samples made easy
• Choosing the laboratory best suited to your specifications
• Personalized monitoring by our scientific experts
• Interpretable and validated results for your industrial or regulatory projects

Recommended internal links

To go further in the characterization of your flavonoid extracts, also discover:

• Diosmin dosage : direct precursor of diosmetin
• Determination of total flavonoids : global spectrophotometric method

Since 2020, numerous manufacturers, distributors, and formulators have trusted us for their flavonoid and plant extract analysis needs. Contact our team today for a personalized quote or to discuss your analytical projects with an expert.