Deformulation

What is deformulation?

Deformulation ( or analytical reverse engineering) involves qualitatively and quantitatively identifying the components of a complex formulation, whether it is a cosmetic product, a detergent, a coating, an adhesive, or a polymer. It allows a finished product to be broken down into its chemical constituents, whether they are the majority or present in trace amounts.

This analysis is essential for understanding the structure of a formulation, assessing its regulatory compliance or ensuring its technical reproducibility. It is used in particular in the context of competitive intelligence, reformulation, regulatory compliance (REACH, CLP, INCI) or in the event of a quality dispute.

What is the purpose of a deformulation study?

Deformulation meets several strategic and technical objectives:

• Analyze the composition of a competing product
• Reproduce or reformulate an existing formula
• Identify the causes of a defect or non-conformity
• Check regulatory labeling or INCI compliance
• Detect impurities, allergens or unwanted residues
• Document a regulatory declaration (e.g.: MSDS, Cosmetic File)

It is particularly useful in sectors subject to strong competitive pressure or strict regulatory requirements.

Which matrices are involved?

Deformulation applies to a wide variety of complex products:

• Cosmetics (creams, lotions, shampoos, makeup)
• Household products and detergents
• Coatings, inks, varnishes, paints
• Resins, glues, adhesives
• Engineering plastics and polymers
• Processed food products (texture analysis, additives, etc.)

What techniques are used for deformulation?

Deformulation is based on a combination of advanced analytical techniques, adapted according to the chemical and physical nature of the sample. Among the most common:

• GC-MS (gas chromatography-mass spectrometry): to identify volatile and semi-volatile organic compounds
• LC-MS (high-performance liquid chromatography with mass spectrometry): for thermosensitive or polar compounds
• IRTF (Fourier transform infrared spectroscopy): for the functional characterization of chemical bonds
• NMR (nuclear magnetic resonance): to determine the structure of complex organic compounds
• XRD (X-ray diffraction): for the crystalline phase of certain solid ingredients
• ICP-MS or ICP-OES: for the quantification of trace metal elements
• Each analysis is tailored to the desired objective, whether it is a global screening or a targeted search for specific ingredients or contaminants.

Expert support with YesWeLab

At YesWeLab , we provide you with a network of laboratories specialized in formulation analysis, mastering the most advanced deformulation techniques. All are ISO 17025 certified and, where required, COFRAC accredited, guaranteeing reliability and traceability of results.

Our scientific team supports you in:

• Define the deformulation protocol adapted to your product
• Prioritize techniques according to your budget and your end goal
• Interpret the results in a comprehensive technical report
• Ensure absolute confidentiality of the information transmitted

Our secure digital platform allows you to submit your requests, track your projects and retrieve your results with ease.

Need to deformulate a complex product?

YesWeLab supports you in your cosmetic, chemical, food, or technical deformulation projects.
Contact our team today to get a personalized quote or discuss your specific analytical reverse engineering needs.