Angelicin Dosage

Angelicin is a furanocoumarin naturally present in several plants, including angelica (Angelica archangelica), parsley, figs, and certain Apiaceae. This compound is known for its photosensitizing effects and its involvement in various biological mechanisms, notably the activation or inhibition of metabolic pathways linked to oxidative stress. Its measurement has become essential in many sectors to ensure the safety, compliance, and quality of products containing plant extracts.

In the nutraceutical, natural cosmetic, and phytotherapeutic sectors, the presence of angelicin must be precisely controlled. Furanocoumarins are among the regulated compounds due to their phototoxic potential. An overdose can pose risks during topical application, while an under-quantification can compromise the standardization of extracts intended for the formulation of active ingredients.

For manufacturers, distributors or formulators, having a reliable analytical result not only secures products before they are placed on the market, but also provides a guarantee of quality and transparency, essential for audits, certifications or communication with end customers.

Analytical methods used for the determination of angelicin

Angelicin assays rely primarily on chromatographic methods, which offer excellent specificity and quantification even at very low concentrations. The most commonly used techniques are:

• HPLC with UV detection, commonly used for plant extracts and standardized products
• LC-MS or LC-MS/MS, essential for complex matrices or trace element analysis
• Specific methods dedicated to furanocoumarins, sometimes including a selective extraction step to eliminate interference.

These methods guarantee optimal reproducibility, a low level of analytical noise and an excellent ability to discriminate angelicin from other structurally similar molecules, such as psoralen or imperatorin.

The parameters measured include the mass concentration of angelicin (mg/kg or mg/g), the relative purity in an extract, or the presence of any associated derivatives.

Matrices analyzed in the context of angelicin assay

The test is applicable to many plant-based matrices or industrial formulations, including:

• dry extracts or hydroalcoholic extracts
• vegetable powders
• essential oils or aromatic fractions
• finished plant-based products
• natural creams, gels or serums
• dietary supplements and capsules

Depending on the matrix, specific preparation may be required (dilution, solid-liquid extraction, SPE purification). The method is selected based on the nature of the product, regulatory requirements, and desired limits of quantification.

Industrial applications of angelicin assay

Angelicin measurement primarily concerns three main areas:

Natural cosmetics:
Control of photosensitizing extracts, securing illuminating formulations, compliance testing with regulations concerning furanocoumarins in products intended for UV exposure.

Nutraceuticals and food supplements
Standardization of plant extracts rich in coumarins or active molecules, control of polyphenolic profiles, verification of batches of raw materials.

Medicinal plants and aromatherapy
Quantification in essential oils or technical extracts, quality control of natural ingredients, batch characterization for manufacturers and distributors.

In all cases, the dosage ensures perfect control of the phototoxic risk while meeting regulatory requirements, particularly for products intended for cutaneous application.

Additional analyses useful for the same matrices

For a comprehensive approach to characterizing plant extracts, the following analyses may be recommended:

• apigenin assay
• quercetin dosage
• chromatography of total polyphenols
• dosage of coumarins and derivatives

Why have your angelicin levels measured with YesWeLab?

Thanks to its network of over 200 partner laboratories, YesWeLab offers analyses tailored to each matrix, using reliable methods that meet industry requirements. The laboratories involved are selected based on the necessary techniques, available accreditations (ISO 17025, COFRAC), and the specific characteristics of your product. The platform simplifies management: requesting quotes, tracking samples, and receiving results all in one place.

For any technical request, specific need or analytical support, our scientific team is available to guide you and offer you the most suitable solution for your project.