Alpha-mangostin (xanthone) dosage

Alpha-mangostin is a bioactive xanthone naturally present in the pericarp of the mangosteen (Garcinia mangostana), a tropical fruit widely used in Asian nutraceuticals and herbal medicine. Recognized for its powerful antioxidant, anti-inflammatory, antimicrobial, and anticancer effects, alpha-mangostin is attracting increasing interest in the development of dietary supplements, standardized botanical extracts, cosmetic products, and functional nutrition applications.

Alpha-mangostin measurement is essential to ensure the quality, efficacy, and compliance of mangosteen extracts used as active ingredients. It allows for standardization of formulations, assessment of compound stability during storage or processing, and traceability of plant-based raw materials.

Why dose alpha-mangostin?

Alpha-mangostin is the main marker of the xanthonoid fraction of mangosteen. It is particularly studied for its multiple biological effects demonstrated in vitro and in vivo:

• Powerful antioxidant properties (free radical scavenging, cell protection)
• Anti-inflammatory effects via inhibition of COX-2 and TNF-α
• Antibacterial and antifungal activity, particularly against oral and intestinal pathogens
• Anticancer potential (cell apoptosis, inhibition of tumor proliferation)

In this context, the dosage of alpha-mangostin becomes a strategic analytical tool for manufacturers of food supplements, formulators of plant extracts, R&D laboratories or biotechnology companies.

Proposed analytical methods

At YesWeLab, we offer several robust techniques for the identification and quantification of alpha-mangostin in different matrices:

• HPLC-DAD (liquid chromatography with UV detection): standard method for simple extracts, with specific detection at 320-340 nm.
• LC-MS/MS (liquid chromatography coupled with tandem mass spectrometry): ideal for complex matrices, increased sensitivity and rigorous traceability requirements.

These methods can be carried out according to internally validated protocols or according to pharmacopoeias, with the possibility of adaptation to the specific specifications of the industry.

Affected matrices

Alpha-mangostin dosage can be applied to a wide range of herbal products:

• Standardized dry extracts of mangosteen
• Micronized pericarp powders
• Concentrated juices or liquid mixes
• Capsules, tablets, functional drinks
• Formulations with antioxidant or anti-inflammatory properties

The analysis can also be used to validate the stability of the active ingredient in aging or comparative efficacy tests.

Additional analyses available

For a comprehensive approach to the quality of mangosteen extracts, we recommend combining this analysis with other targeted assays:

• Total polyphenol assay (Folin-Ciocalteu) – to assess overall antioxidant activity
• Xanthone Assay – For a Full Spectrum of Xanthonoid Compounds
• Vitamin C (ascorbic acid) dosage – often found in antioxidant formulations
• Antioxidant activity assay (DPPH, ORAC, ABTS) – to enhance functional claims

Compliance, valuation and quality control

Although alpha-mangostin is not currently classified as a regulated substance in Europe, products containing mangosteen extracts must comply with the requirements relating to:

• To the INCO regulation for the labeling of food supplements
• To the requirements of traceability, standardization and stability
• To the declaration of active ingredients in Novel Food or nutrivigilance files
• To the absence of contaminants or adulteration (e.g. botanical substitution or fraudulent dilution)

Thanks to the alpha-mangostin dosage, you benefit from reliable analytical control to guarantee the compliance and added value of your formulations.

YesWeLab, expert in nutraceutical analyzes

Since 2020, YesWeLab has been supporting manufacturers, formulators, distributors, and design offices in managing their analyses. Our digital platform centralizes more than 2,000 analytical services related to plant-based ingredients, functional active ingredients, nutritional extracts, and innovative formulations.

We select the most suitable laboratory for you, from a rigorously audited network (ISO 17025, COFRAC, pharmacopoeias, GLP validation if necessary).

Add this analysis to your quote request or contact our scientific team for personalized support. Fast results, technical advice, and responsiveness guaranteed.