Acetylsalicylic acid assay

Acetylsalicylic acid , better known as aspirin, is a derivative of salicylic acid widely used for its anti-inflammatory, analgesic, and antipyretic properties. Although primarily used in pharmaceuticals, it is also found in some dietary supplements, herbal formulations, and products for technical or research purposes.

Its dosage is essential for quality control, standardization of plant extracts (particularly for anti-inflammatory purposes), as well as the verification of experimental formulations in innovative sectors such as nutraceuticals.

Analytical methods available: HPLC-DAD and LC-MS

Acetylsalicylic acid is measured by liquid chromatography:

• HPLC-DAD (High Performance Liquid Chromatography with UV/diode array detection): reference method for the analysis of active substances in plant or semi-complex matrices.
• LC-MS (Liquid Chromatography coupled with Mass Spectrometry): used for matrices with low concentration or requiring high specificity.

Depending on the analytical objectives, monitoring of degradation into salicylic acid can also be carried out to assess the stability of the molecule over time.

Why measure acetylsalicylic acid?

The measurement of this compound is useful in several industrial or regulatory contexts:

• Verification of the actual composition of a food supplement
• Verification of the authenticity of plant extracts, particularly those derived from Salix alba (white willow) or other plants rich in salicylates
• Formulation control for innovative or technically focused products (cosmeceutical, nutraceutical, dermo-cosmetic)
• Stability studies or development of research products containing salicylates
• Risk assessment of exceeding regulatory thresholds in certain contexts of active ingredients or residues

Affected matrices

Our partner laboratories have the expertise and equipment necessary to analyze acetylsalicylic acid in a wide variety of matrices:

• Extracts of medicinal plants rich in salicylates
• Research or development formulations
• Nutraceutical powders, capsules or tablets
• Experimental or semi-finished products
• Technical cosmetics or formulation prototypes

Appropriate extraction and purification protocols ensure reliable quantification, even in the most complex matrices.

Areas of application

Acetylsalicylic acid measurement is relevant to several industrial sectors:

• Nutraceuticals: securing formulations combining plant extracts and natural active compounds
• Functional nutrition: validation of the absence or controlled presence of salicylate derivatives
• Medicinal plants: standardization of extracts from willows or other natural sources of salicylates
• Cosmetics and dermo-cosmetics: verification of technical formulas with soothing or exfoliating action
• Applied research: formulation, stability, bioavailability, preclinical trials

YesWeLab: a network of experts at your service for your analyses

YesWeLab provides you with a unique digital platform for ordering, centralizing, and tracking your analyses. We collaborate with a network of ISO 17025 or equivalent accredited laboratories specializing in physicochemical analysis and chromatography.

Our scientific team supports you at every stage: method selection, results interpretation, and customization of the analytical service. Each request is handled confidentially, rigorously, and responsively.

Further analyses recommended

• Salicylic acid assay
• Total salicylate content
• Quercetin (flavonoid) dosage

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Need to verify the acetylsalicylic acid concentration in your extracts or products? Describe your objectives and specific requirements. YesWeLab will support you with a personalized, fast analytical service that meets the standards of your industry.